======= SLIT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLIT2
  * **<color #00a2e8>Official Name</color>**: slit guidance ligand 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9353|9353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94813|O94813]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLIT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLIT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603746|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF|
|Laminin G 2|
|LRRNT|
|Laminin G 1|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|corticospinal neuron axon guidance through spinal cord|
|induction of negative chemotaxis|
|positive regulation of negative chemotaxis|
|negative regulation of retinal ganglion cell axon guidance|
|postnatal olfactory bulb interneuron migration|
|negative regulation of neutrophil chemotaxis|
|negative regulation of granulocyte chemotaxis|
|corticospinal neuron axon guidance|
|cerebral cortex tangential migration using cell-cell interactions|
|chemorepulsion involved in postnatal olfactory bulb interneuron migration|
|negative regulation of neutrophil migration|
|apoptotic process involved in luteolysis|
|negative regulation of lamellipodium assembly|
|chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration|
|embryonic olfactory bulb interneuron precursor migration|
|regulation of negative chemotaxis|
|negative regulation of smooth muscle cell chemotaxis|
|negative regulation of lamellipodium organization|
|substrate-dependent cerebral cortex tangential migration|
|regulation of retinal ganglion cell axon guidance|
|Roundabout signaling pathway|
|cellular response to heparin|
|response to cortisol|
|laminin-1 binding|
|negative regulation of monocyte chemotaxis|
|response to heparin|
|luteolysis|
|regulation of smooth muscle cell chemotaxis|
|corticospinal tract morphogenesis|
|negative regulation of chemokine-mediated signaling pathway|
|tangential migration from the subventricular zone to the olfactory bulb|
|Roundabout binding|
|response to anticoagulant|
|axon extension involved in axon guidance|
|negative regulation of mononuclear cell migration|
|neuron projection extension involved in neuron projection guidance|
|cerebral cortex tangential migration|
|olfactory bulb interneuron development|
|regulation of chemokine-mediated signaling pathway|
|negative regulation of vascular permeability|
|substrate-independent telencephalic tangential interneuron migration|
|substrate-independent telencephalic tangential migration|
|GTPase inhibitor activity|
|olfactory bulb interneuron differentiation|
|proteoglycan binding|
|pulmonary valve morphogenesis|
|negative regulation of leukocyte chemotaxis|
|retinal ganglion cell axon guidance|
|cell migration involved in sprouting angiogenesis|
|pulmonary valve development|
|negative regulation of smooth muscle cell migration|
|regulation of monocyte chemotaxis|
|negative regulation of plasma membrane bounded cell projection assembly|
|central nervous system projection neuron axonogenesis|
|substrate-dependent cell migration|
|apoptotic process involved in development|
|aortic valve morphogenesis|
|negative regulation of axon guidance|
|motor neuron axon guidance|
|regulation of neutrophil chemotaxis|
|regulation of lamellipodium assembly|
|blood vessel endothelial cell migration|
|forebrain neuron development|
|aortic valve development|
|olfactory bulb development|
|olfactory lobe development|
|axon extension|
|central nervous system neuron axonogenesis|
|regulation of vascular permeability|
|regulation of neutrophil migration|
|semi-lunar valve development|
|ventricular septum morphogenesis|
|regulation of lamellipodium organization|
|cerebral cortex cell migration|
|regulation of granulocyte chemotaxis|
|ovulation cycle process|
|regulation of axon guidance|
|negative regulation of leukocyte migration|
|negative chemotaxis|
|negative regulation of GTPase activity|
|regulation of mononuclear cell migration|
|negative regulation of endothelial cell migration|
|forebrain neuron differentiation|
|negative regulation of actin filament polymerization|
|heart valve morphogenesis|
|negative regulation of chemotaxis|
|sprouting angiogenesis|
|telencephalon cell migration|
|negative regulation of small GTPase mediated signal transduction|
|neuron projection extension|
|regulation of smooth muscle cell migration|
|negative regulation of cytokine-mediated signaling pathway|
|heart valve development|
|forebrain cell migration|
|endothelial cell migration|
|negative regulation of response to cytokine stimulus|
|negative regulation of protein polymerization|
|negative regulation of epithelial cell migration|
|forebrain generation of neurons|
|ovulation cycle|
|negative regulation of axonogenesis|
|ventricular septum development|
|cardiac septum morphogenesis|
|central nervous system neuron development|
|epithelial cell migration|
|positive regulation of axonogenesis|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|epithelium migration|
|female gonad development|
|developmental cell growth|
|cell growth|
|mesonephros development|
|development of primary female sexual characteristics|
|tissue migration|
|negative regulation of cell morphogenesis involved in differentiation|
|female sex differentiation|
|cardiac septum development|
|regulation of leukocyte chemotaxis|
|developmental growth involved in morphogenesis|
|cerebral cortex development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|kidney epithelium development|
|negative regulation of protein complex assembly|
|branching morphogenesis of an epithelial tube|
|negative regulation of supramolecular fiber organization|
|positive regulation of chemotaxis|
|negative regulation of cytoskeleton organization|
|response to glucocorticoid|
|negative regulation of cellular response to growth factor stimulus|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of endothelial cell migration|
|morphogenesis of a branching epithelium|
|response to corticosteroid|
|regulation of cytokine-mediated signaling pathway|
|regulation of actin filament polymerization|
|morphogenesis of a branching structure|
|vascular process in circulatory system|
|cardiac chamber development|
|heparin binding|
|ameboidal-type cell migration|
|pallium development|
|regulation of response to cytokine stimulus|
|central nervous system neuron differentiation|
|negative regulation of cell projection organization|
|regulation of actin polymerization or depolymerization|
|negative regulation of cell growth|
|regulation of actin filament length|
|regulation of axonogenesis|
|response to ketone|
|regulation of leukocyte migration|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|gonad development|
|regulation of chemotaxis|
|development of primary sexual characteristics|
|regulation of epithelial cell migration|
|regulation of protein polymerization|
|negative regulation of neuron differentiation|
|response to alcohol|
|negative regulation of growth|
|heart morphogenesis|
|telencephalon development|
|negative regulation of cell migration|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|sex differentiation|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|rhythmic process|
|positive regulation of neuron projection development|
|renal system development|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|angiogenesis|
|urogenital system development|
|negative regulation of locomotion|
|response to steroid hormone|
|negative regulation of cell development|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|cellular process involved in reproduction in multicellular organism|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|axonogenesis|
|negative regulation of organelle organization|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|forebrain development|
|developmental growth|
|regulation of actin filament-based process|
|blood circulation|
|growth|
|circulatory system process|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|axon development|
|regulation of cell growth|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|negative regulation of intracellular signal transduction|
|vasculature development|
|regulation of anatomical structure size|
|cell part morphogenesis|
|cardiovascular system development|
|heart development|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|calcium ion binding|
|cell morphogenesis|
|brain development|
|head development|
|negative regulation of catalytic activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|epithelium development|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.92|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11379
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLIT2 Expression in NALM6 Cells: -2.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>