======= SLIT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLIT3
  * **<color #00a2e8>Official Name</color>**: slit guidance ligand 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6586|6586]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75094|O75094]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLIT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLIT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603745|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRRNT|
|Laminin G 2|
|EGF|
|Laminin G 1|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration|
|apoptotic process involved in luteolysis|
|embryonic olfactory bulb interneuron precursor migration|
|Roundabout signaling pathway|
|response to cortisol|
|negative regulation of chemokine-mediated signaling pathway|
|luteolysis|
|tangential migration from the subventricular zone to the olfactory bulb|
|Roundabout binding|
|neuron projection extension involved in neuron projection guidance|
|axon extension involved in axon guidance|
|olfactory bulb interneuron development|
|regulation of chemokine-mediated signaling pathway|
|substrate-independent telencephalic tangential migration|
|substrate-independent telencephalic tangential interneuron migration|
|olfactory bulb interneuron differentiation|
|atrioventricular valve morphogenesis|
|atrioventricular valve development|
|apoptotic process involved in development|
|aortic valve morphogenesis|
|forebrain neuron development|
|olfactory bulb development|
|aortic valve development|
|olfactory lobe development|
|axon extension|
|semi-lunar valve development|
|ventricular septum morphogenesis|
|ovulation cycle process|
|negative chemotaxis|
|forebrain neuron differentiation|
|heart valve morphogenesis|
|telencephalon cell migration|
|neuron projection extension|
|heart valve development|
|negative regulation of cytokine-mediated signaling pathway|
|forebrain cell migration|
|negative regulation of response to cytokine stimulus|
|forebrain generation of neurons|
|ovulation cycle|
|ventricular septum development|
|cardiac septum morphogenesis|
|central nervous system neuron development|
|female gonad development|
|developmental cell growth|
|cell growth|
|development of primary female sexual characteristics|
|female sex differentiation|
|cardiac septum development|
|developmental growth involved in morphogenesis|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|response to glucocorticoid|
|response to corticosteroid|
|regulation of cytokine-mediated signaling pathway|
|heparin binding|
|cardiac chamber development|
|regulation of response to cytokine stimulus|
|central nervous system neuron differentiation|
|negative regulation of cell growth|
|response to ketone|
|gonad development|
|development of primary sexual characteristics|
|response to alcohol|
|negative regulation of growth|
|heart morphogenesis|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|sex differentiation|
|rhythmic process|
|response to steroid hormone|
|cellular process involved in reproduction in multicellular organism|
|axonogenesis|
|forebrain development|
|developmental growth|
|growth|
|axon development|
|regulation of cell growth|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|heart development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|cellular response to hormone stimulus|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|calcium ion binding|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|circulatory system development|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|animal organ morphogenesis|
|cell migration|
|central nervous system development|
|neuron differentiation|
|response to drug|
|programmed cell death|
|cell motility|
|localization of cell|
|cell death|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|mitochondrion|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.05|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.74|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.02|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8832
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLIT3 Expression in NALM6 Cells: 1.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>