======= SMG7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMG7
  * **<color #00a2e8>Official Name</color>**: SMG7 nonsense mediated mRNA decay factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9887|9887]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92540|Q92540]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMG7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMG7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610964|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EST1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|telomerase holoenzyme complex|
|telomerase RNA binding|
|telomere maintenance via telomerase|
|telomeric DNA binding|
|telomere maintenance via telomere lengthening|
|protein phosphatase 2A binding|
|RNA-dependent DNA biosynthetic process|
|intermediate filament cytoskeleton|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|regulation of telomere maintenance|
|telomere maintenance|
|telomere organization|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|DNA biosynthetic process|
|regulation of DNA biosynthetic process|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|regulation of dephosphorylation|
|RNA localization|
|mRNA catabolic process|
|nucleobase-containing compound transport|
|RNA catabolic process|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|mRNA metabolic process|
|DNA metabolic process|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.85|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.73|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.52|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.47|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.43|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.42|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.41|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.28|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.23|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.23|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.21|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.21|
|[[:results:exp539|42°C R08 exp539]]|-2.17|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.16|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.15|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.14|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.11|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.11|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.05|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.05|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.03|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.97|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.94|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.91|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.9|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.89|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.86|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.85|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.79|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.78|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.78|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.74|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.73|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.71|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.7|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.73|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.75|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.83|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.87|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.88|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.89|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.94|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2.09|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfand5|ZFAND5]]|0.677|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.58|
|[[:human genes:s:smg1|SMG1]]|0.578|
|[[:human genes:a:atp13a1|ATP13A1]]|0.57|
|[[:human genes:p:pan2|PAN2]]|0.564|
|[[:human genes:p:pan3|PAN3]]|0.55|
|[[:human genes:p:psmc2|PSMC2]]|0.546|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.545|
|[[:human genes:p:psmd1|PSMD1]]|0.539|
|[[:human genes:p:psmc1|PSMC1]]|0.535|
|[[:human genes:n:nup188|NUP188]]|0.524|
|[[:human genes:v:vasn|VASN]]|0.523|
|[[:human genes:p:psmd11|PSMD11]]|0.518|
|[[:human genes:w:wdr43|WDR43]]|0.509|
|[[:human genes:m:myo1h|MYO1H]]|0.5|
|[[:human genes:c:chd4|CHD4]]|0.496|
|[[:human genes:s:smg5|SMG5]]|0.493|
|[[:human genes:s:supt6h|SUPT6H]]|0.491|
|[[:human genes:c:cdca3|CDCA3]]|0.49|
|[[:human genes:p:psmb1|PSMB1]]|0.488|
|[[:human genes:r:rpl14|RPL14]]|0.486|
|[[:human genes:m:mdm2|MDM2]]|0.486|
|[[:human genes:c:cdk12|CDK12]]|0.482|
|[[:human genes:s:scaf1|SCAF1]]|0.481|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.48|
|[[:human genes:d:ddtl|DDTL]]|0.479|
|[[:human genes:p:psma6|PSMA6]]|0.477|
|[[:human genes:t:terf1|TERF1]]|0.477|
|[[:human genes:p:paf1|PAF1]]|0.475|
|[[:human genes:c:cope|COPE]]|0.467|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.466|
|[[:human genes:k:kpnb1|KPNB1]]|0.466|
|[[:human genes:c:chmp2a|CHMP2A]]|0.465|
|[[:human genes:h:hap1|HAP1]]|0.465|
|[[:human genes:p:pola2|POLA2]]|0.465|
|[[:human genes:p:plcg2|PLCG2]]|0.463|
|[[:human genes:d:dtl|DTL]]|0.461|
|[[:human genes:o:orc1|ORC1]]|0.461|
|[[:human genes:t:terf2|TERF2]]|0.461|
|[[:human genes:r:rps28|RPS28]]|0.461|
|[[:human genes:r:rpl35|RPL35]]|0.46|
|[[:human genes:c:cbwd3|CBWD3]]|0.46|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.459|
|[[:human genes:p:psmd14|PSMD14]]|0.459|
|[[:human genes:p:psma7|PSMA7]]|0.459|
|[[:human genes:a:adrm1|ADRM1]]|0.458|
|[[:human genes:h:hivep3|HIVEP3]]|0.457|
|[[:human genes:s:smg6|SMG6]]|0.455|
|[[:human genes:z:znf106|ZNF106]]|0.455|
|[[:human genes:a:ankle2|ANKLE2]]|0.455|
|[[:human genes:r:rad51|RAD51]]|0.453|
|[[:human genes:i:igfn1|IGFN1]]|0.452|
|[[:human genes:n:nop16|NOP16]]|0.452|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.451|
|[[:human genes:s:ssh2|SSH2]]|0.45|
|[[:human genes:d:dido1|DIDO1]]|0.449|
|[[:human genes:m:med17|MED17]]|0.449|
|[[:human genes:t:tra2b|TRA2B]]|0.449|
|[[:human genes:a:aaas|AAAS]]|0.448|
|[[:human genes:c:ccna2|CCNA2]]|0.448|
|[[:human genes:c:cdc73|CDC73]]|0.447|
|[[:human genes:d:ddx21|DDX21]]|0.447|
|[[:human genes:t:ticrr|TICRR]]|0.446|
|[[:human genes:p:psmc6|PSMC6]]|0.444|
|[[:human genes:m:myh7b|MYH7B]]|0.44|
|[[:human genes:u:uqcrh|UQCRH]]|0.44|
|[[:human genes:n:narfl|NARFL]]|0.44|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.439|
|[[:human genes:c:cnot1|CNOT1]]|0.439|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.438|
|[[:human genes:i:ik|IK]]|0.438|
|[[:human genes:p:ppm1d|PPM1D]]|0.438|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.438|
|[[:human genes:p:psma1|PSMA1]]|0.437|
|[[:human genes:r:rbm39|RBM39]]|0.436|
|[[:human genes:c:copb1|COPB1]]|0.436|
|[[:human genes:e:exosc9|EXOSC9]]|0.434|
|[[:human genes:r:rpl30|RPL30]]|0.434|
|[[:human genes:m:mul1|MUL1]]|0.433|
|[[:human genes:c:c14orf93|C14orf93]]|0.433|
|[[:human genes:a:akirin2|AKIRIN2]]|0.433|
|[[:human genes:r:rpsa|RPSA]]|0.432|
|[[:human genes:a:acsf2|ACSF2]]|0.432|
|[[:human genes:t:tceb3c|TCEB3C]]|0.432|
|[[:human genes:n:ndc1|NDC1]]|0.431|
|[[:human genes:c:cbwd6|CBWD6]]|0.431|
|[[:human genes:m:mt1e|MT1E]]|0.43|
|[[:human genes:e:eif3k|EIF3K]]|0.43|
|[[:human genes:a:arcn1|ARCN1]]|0.43|
|[[:human genes:s:sel1l|SEL1L]]|0.429|
|[[:human genes:p:psmc4|PSMC4]]|0.429|
|[[:human genes:t:traip|TRAIP]]|0.429|
|[[:human genes:r:rps2|RPS2]]|0.428|
|[[:human genes:k:kctd17|KCTD17]]|0.427|
|[[:human genes:i:ino80e|INO80E]]|0.426|
|[[:human genes:d:disp2|DISP2]]|0.426|
|[[:human genes:p:psmb4|PSMB4]]|0.426|
|[[:human genes:x:xylt2|XYLT2]]|0.426|
|[[:human genes:r:rsl1d1|RSL1D1]]|0.426|
|[[:human genes:u:upf1|UPF1]]|0.426|
|[[:human genes:a:ahctf1|AHCTF1]]|0.425|
|[[:human genes:x:xiap|XIAP]]|0.425|
|[[:human genes:r:rps3|RPS3]]|0.424|
|[[:human genes:r:rpl38|RPL38]]|0.424|
|[[:human genes:m:mbtd1|MBTD1]]|0.424|
|[[:human genes:p:polr2d|POLR2D]]|0.424|
|[[:human genes:a:ankle1|ANKLE1]]|0.423|
|[[:human genes:s:syt9|SYT9]]|0.422|
|[[:human genes:t:twistnb|TWISTNB]]|0.422|
|[[:human genes:c:cbwd5|CBWD5]]|0.422|
|[[:human genes:r:rps14|RPS14]]|0.422|
|[[:human genes:o:ogfr|OGFR]]|0.422|
|[[:human genes:c:c19orf53|C19orf53]]|0.422|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.419|
|[[:human genes:p:psmd7|PSMD7]]|0.418|
|[[:human genes:s:s1pr4|S1PR4]]|0.418|
|[[:human genes:n:napa|NAPA]]|0.417|
|[[:human genes:n:nupl1|NUPL1]]|0.416|
|[[:human genes:n:nbpf10|NBPF10]]|0.416|
|[[:human genes:r:ranbp2|RANBP2]]|0.416|
|[[:human genes:p:psmc3|PSMC3]]|0.415|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.414|
|[[:human genes:c:ccdc116|CCDC116]]|0.413|
|[[:human genes:r:rrn3|RRN3]]|0.412|
|[[:human genes:e:eif3l|EIF3L]]|0.412|
|[[:human genes:t:taf1|TAF1]]|0.409|
|[[:human genes:o:orc6|ORC6]]|0.409|
|[[:human genes:s:slc4a1|SLC4A1]]|0.406|
|[[:human genes:m:myt1l|MYT1L]]|0.406|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.405|
|[[:human genes:n:nol10|NOL10]]|0.405|
|[[:human genes:e:ell|ELL]]|0.405|
|[[:human genes:u:ubap1|UBAP1]]|0.405|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.405|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.404|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.404|
|[[:human genes:m:med29|MED29]]|0.403|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.403|
|[[:human genes:e:eif4a3|EIF4A3]]|0.402|
|[[:human genes:c:clptm1|CLPTM1]]|0.401|
|[[:human genes:c:cln6|CLN6]]|0.4|
|[[:human genes:n:nip7|NIP7]]|0.4|
|[[:human genes:l:lad1|LAD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 43/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|3/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|2/20|
|lung|6/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 321
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMG7 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>