======= SMO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMO
  * **<color #00a2e8>Official Name</color>**: smoothened, frizzled class receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6608|6608]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99835|Q99835]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601500|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:P56726, ECO:0000269|PubMed:19592253}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fz|
|Frizzled|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of cell density|
|detection of cell density by contact stimulus|
|mesenchymal to epithelial transition involved in renal vesicle formation|
|mesenchymal to epithelial transition involved in metanephric renal vesicle formation|
|detection of cell density by contact stimulus involved in contact inhibition|
|ventral midline determination|
|positive regulation of hh target transcription factor activity|
|ventral midline development|
|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|
|negative regulation of hair follicle development|
|smoothened signaling pathway involved in ventral spinal cord patterning|
|signal transduction downstream of smoothened|
|pancreas morphogenesis|
|metanephric renal vesicle formation|
|negative regulation of hair cycle|
|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|
|epithelial-mesenchymal cell signaling|
|renal vesicle formation|
|determination of left/right asymmetry in lateral mesoderm|
|mesenchymal to epithelial transition involved in metanephros morphogenesis|
|positive regulation of cerebellar granule cell precursor proliferation|
|patched binding|
|contact inhibition|
|metanephric renal vesicle morphogenesis|
|regulation of cerebellar granule cell precursor proliferation|
|forebrain morphogenesis|
|lateral mesoderm development|
|renal vesicle morphogenesis|
|commissural neuron axon guidance|
|myoblast migration|
|midgut development|
|left/right axis specification|
|thalamus development|
|renal vesicle development|
|type B pancreatic cell development|
|mesenchymal to epithelial transition|
|atrial septum morphogenesis|
|dentate gyrus development|
|mammary gland epithelial cell differentiation|
|dorsal/ventral neural tube patterning|
|cell differentiation involved in metanephros development|
|cellular response to cholesterol|
|positive regulation of branching involved in ureteric bud morphogenesis|
|negative regulation of epidermis development|
|glandular epithelial cell development|
|astrocyte activation|
|type B pancreatic cell differentiation|
|regulation of hair follicle development|
|enteroendocrine cell differentiation|
|metanephric nephron morphogenesis|
|atrial septum development|
|positive regulation of mesonephros development|
|cellular response to sterol|
|left/right pattern formation|
|spinal cord dorsal/ventral patterning|
|positive regulation of neuroblast proliferation|
|regulation of branching involved in ureteric bud morphogenesis|
|muscle cell migration|
|detection of biotic stimulus|
|skeletal muscle fiber development|
|spinal cord patterning|
|positive regulation of mesenchymal cell proliferation|
|hair follicle morphogenesis|
|regulation of mesonephros development|
|response to cholesterol|
|myotube cell development|
|metanephros morphogenesis|
|regulation of hair cycle|
|regulation of stem cell population maintenance|
|epidermis morphogenesis|
|cardiac atrium morphogenesis|
|epithelial cell differentiation involved in kidney development|
|cerebellar cortex morphogenesis|
|response to sterol|
|homeostasis of number of cells within a tissue|
|metanephric nephron development|
|positive regulation of smoothened signaling pathway|
|positive regulation of multicellular organism growth|
|regulation of neuroblast proliferation|
|brain morphogenesis|
|regulation of mesenchymal cell proliferation|
|positive regulation of morphogenesis of an epithelium|
|neural tube patterning|
|cardiac atrium development|
|astrocyte development|
|positive regulation of protein import into nucleus|
|cerebellum morphogenesis|
|glandular epithelial cell differentiation|
|glial cell activation|
|endocrine pancreas development|
|positive regulation of protein import|
|positive regulation of stem cell proliferation|
|regulation of heart morphogenesis|
|positive regulation of kidney development|
|hindbrain morphogenesis|
|cell differentiation involved in kidney development|
|neuroinflammatory response|
|negative regulation of epithelial cell differentiation|
|ciliary tip|
|cerebellar cortex development|
|positive regulation of organ growth|
|columnar/cuboidal epithelial cell development|
|positive regulation of neural precursor cell proliferation|
|astrocyte differentiation|
|ciliary membrane|
|negative regulation of DNA binding|
|neural crest cell migration|
|regulation of protein import into nucleus|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|myotube differentiation|
|drug binding|
|muscle fiber development|
|mammary gland epithelium development|
|regulation of protein import|
|heart looping|
|positive regulation of nucleocytoplasmic transport|
|regulation of stem cell proliferation|
|regulation of multicellular organism growth|
|nephron epithelium morphogenesis|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|nephron morphogenesis|
|endocytic vesicle membrane|
|vasculogenesis|
|hair follicle development|
|pancreas development|
|smoothened signaling pathway|
|skin epidermis development|
|cardiac septum morphogenesis|
|caveola|
|molting cycle process|
|positive regulation of protein localization to nucleus|
|hair cycle process|
|diencephalon development|
|embryonic heart tube development|
|regulation of smoothened signaling pathway|
|neural crest cell development|
|dorsal/ventral pattern formation|
|hippocampus development|
|positive regulation of animal organ morphogenesis|
|odontogenesis of dentin-containing tooth|
|somite development|
|multicellular organism growth|
|stem cell development|
|metanephros development|
|mesenchymal cell development|
|cellular response to alcohol|
|kidney morphogenesis|
|axis specification|
|regulation of epidermis development|
|cell fate specification|
|regulation of neural precursor cell proliferation|
|neural crest cell differentiation|
|molting cycle|
|hair cycle|
|regulation of organ growth|
|columnar/cuboidal epithelial cell differentiation|
|nephron epithelium development|
|cerebellum development|
|regulation of nucleocytoplasmic transport|
|glial cell development|
|spinal cord development|
|limbic system development|
|cardiac septum development|
|metencephalon development|
|cerebral cortex development|
|regulation of protein localization to nucleus|
|determination of left/right symmetry|
|odontogenesis|
|endocrine system development|
|determination of bilateral symmetry|
|skeletal muscle tissue development|
|mesoderm development|
|nephron development|
|specification of symmetry|
|regulation of DNA binding|
|cardiac chamber morphogenesis|
|osteoblast differentiation|
|mammary gland development|
|kidney epithelium development|
|digestive tract development|
|skeletal muscle organ development|
|striated muscle cell development|
|regulation of epithelial cell differentiation|
|digestive system development|
|muscle cell development|
|hindbrain development|
|positive regulation of intracellular protein transport|
|mesenchymal cell differentiation|
|stem cell differentiation|
|neural tube development|
|protein localization to nucleus|
|glial cell differentiation|
|negative regulation of binding|
|cardiac chamber development|
|positive regulation of developmental growth|
|ameboidal-type cell migration|
|pallium development|
|protein stabilization|
|central nervous system neuron differentiation|
|regulation of morphogenesis of an epithelium|
|positive regulation of epithelial cell proliferation|
|tissue homeostasis|
|epithelial cell development|
|cilium|
|homeostasis of number of cells|
|striated muscle cell differentiation|
|positive regulation of intracellular transport|
|gliogenesis|
|anterior/posterior pattern specification|
|mesenchyme development|
|regulation of intracellular protein transport|
|response to alcohol|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|telencephalon development|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|axon guidance|
|neuron projection guidance|
|ossification|
|positive regulation of DNA-binding transcription factor activity|
|kidney development|
|renal system development|
|striated muscle tissue development|
|regulation of protein stability|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|urogenital system development|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|regulation of developmental growth|
|regionalization|
|regulation of epithelial cell proliferation|
|anatomical structure homeostasis|
|regulation of intracellular transport|
|axonogenesis|
|in utero embryonic development|
|regulation of binding|
|skin development|
|forebrain development|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|axon development|
|gland development|
|epidermis development|
|dendrite|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|pattern specification process|
|positive regulation of establishment of protein localization|
|positive regulation of neurogenesis|
|muscle structure development|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|inflammatory response|
|positive regulation of cell migration|
|vasculature development|
|cell part morphogenesis|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of cell motility|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|regulation of growth|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|detection of stimulus|
|regulation of protein transport|
|negative regulation of cell differentiation|
|cell morphogenesis|
|G protein-coupled receptor activity|
|protein localization to organelle|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.98|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.96|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.72|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7958
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMO Expression in NALM6 Cells: -1.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>