======= SNAI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNAI2
  * **<color #00a2e8>Official Name</color>**: snail family transcriptional repressor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6591|6591]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43623|O43623]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNAI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNAI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. {ECO:0000250, ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:11912130, ECO:0000269|PubMed:15734731, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter|
|desmosome disassembly|
|negative regulation of vitamin D receptor signaling pathway|
|cell migration involved in endocardial cushion formation|
|negative regulation of cell adhesion involved in substrate-bound cell migration|
|negative regulation of vitamin D biosynthetic process|
|negative regulation of vitamin metabolic process|
|regulation of vitamin D receptor signaling pathway|
|regulation of branching involved in salivary gland morphogenesis|
|regulation of vitamin D biosynthetic process|
|desmosome organization|
|negative regulation of cell adhesion mediated by integrin|
|Notch signaling involved in heart development|
|regulation of vitamin metabolic process|
|white fat cell differentiation|
|negative regulation of stem cell proliferation|
|negative regulation of keratinocyte proliferation|
|epithelial to mesenchymal transition involved in endocardial cushion formation|
|cell migration involved in heart development|
|negative regulation of response to extracellular stimulus|
|negative regulation of response to nutrient levels|
|negative regulation of DNA damage response, signal transduction by p53 class mediator|
|negative regulation of anoikis|
|endocardial cushion formation|
|regulation of bicellular tight junction assembly|
|negative regulation of chondrocyte differentiation|
|negative regulation of steroid biosynthetic process|
|cell surface receptor signaling pathway involved in heart development|
|regulation of anoikis|
|regulation of response to nutrient levels|
|regulation of response to extracellular stimulus|
|negative regulation of steroid metabolic process|
|substrate-dependent cell migration|
|cardiac epithelial to mesenchymal transition|
|negative regulation of cartilage development|
|aortic valve morphogenesis|
|cartilage morphogenesis|
|positive regulation of histone acetylation|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|aortic valve development|
|negative regulation of signal transduction by p53 class mediator|
|regulation of keratinocyte proliferation|
|positive regulation of peptidyl-lysine acetylation|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of signal transduction in absence of ligand|
|endocardial cushion morphogenesis|
|semi-lunar valve development|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of protein acetylation|
|cellular response to epidermal growth factor stimulus|
|endocardial cushion development|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|regulation of cell adhesion mediated by integrin|
|response to epidermal growth factor|
|negative regulation of lipid biosynthetic process|
|E-box binding|
|mesenchyme morphogenesis|
|regulation of chondrocyte differentiation|
|heart valve morphogenesis|
|regulation of morphogenesis of a branching structure|
|regulation of histone acetylation|
|positive regulation of fat cell differentiation|
|heart valve development|
|regulation of peptidyl-lysine acetylation|
|regulation of stem cell proliferation|
|cellular response to ionizing radiation|
|regulation of cartilage development|
|epithelial to mesenchymal transition|
|regulation of protein acetylation|
|regulation of chemokine production|
|neural crest cell development|
|negative regulation of response to DNA damage stimulus|
|negative regulation of lipid metabolic process|
|stem cell development|
|mesenchymal cell development|
|regulation of steroid biosynthetic process|
|regulation of cell junction assembly|
|neural crest cell differentiation|
|roof of mouth development|
|negative regulation of small molecule metabolic process|
|positive regulation of histone modification|
|pigmentation|
|negative regulation of intrinsic apoptotic signaling pathway|
|negative regulation of extrinsic apoptotic signaling pathway|
|positive regulation of chromatin organization|
|fat cell differentiation|
|regulation of osteoblast differentiation|
|regulation of steroid metabolic process|
|regulation of fat cell differentiation|
|negative regulation of epithelial cell proliferation|
|Notch signaling pathway|
|osteoblast differentiation|
|cell-cell junction organization|
|regulation of histone modification|
|sensory perception of sound|
|response to ionizing radiation|
|regulation of extrinsic apoptotic signaling pathway|
|mesenchymal cell differentiation|
|stem cell differentiation|
|regulation of intrinsic apoptotic signaling pathway|
|sensory perception of mechanical stimulus|
|cartilage development|
|negative regulation of cell-cell adhesion|
|negative regulation of canonical Wnt signaling pathway|
|cellular response to radiation|
|positive regulation of chromosome organization|
|regulation of morphogenesis of an epithelium|
|regulation of signal transduction by p53 class mediator|
|regulation of lipid biosynthetic process|
|regulation of chromatin organization|
|regulation of ossification|
|negative regulation of Wnt signaling pathway|
|cell junction organization|
|regulation of response to DNA damage stimulus|
|mesenchyme development|
|connective tissue development|
|negative regulation of apoptotic signaling pathway|
|nuclear chromatin|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|ossification|
|negative regulation of cell adhesion|
|regulation of canonical Wnt signaling pathway|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of epithelial cell proliferation|
|regulation of chromosome organization|
|regulation of Wnt signaling pathway|
|negative regulation of response to external stimulus|
|chromatin binding|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|sequence-specific DNA binding|
|regulation of small molecule metabolic process|
|response to radiation|
|skeletal system development|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|tissue morphogenesis|
|positive regulation of organelle organization|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|sensory perception|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|epithelium development|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|tissue development|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.74|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.75|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12552
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNAI2 Expression in NALM6 Cells: -2.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>