======= SNCB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNCB
  * **<color #00a2e8>Official Name</color>**: synuclein beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6620|6620]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16143|Q16143]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNCB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNCB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602569|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Synuclein|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cuprous ion binding|
|phospholipase inhibitor activity|
|transition metal ion binding|
|inclusion body|
|dopamine metabolic process|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|catecholamine metabolic process|
|catechol-containing compound metabolic process|
|synaptic vesicle recycling|
|phenol-containing compound metabolic process|
|presynapse|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|negative regulation of neuron apoptotic process|
|ammonium ion metabolic process|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|synapse organization|
|regulation of neuron death|
|response to metal ion|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|organic hydroxy compound metabolic process|
|synaptic signaling|
|drug metabolic process|
|response to inorganic substance|
|endocytosis|
|import into cell|
|calcium ion binding|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-2.45|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.34|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.87|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.81|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.76|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.72|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.71|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8515
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNCB Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>