======= SNRNP200 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNRNP200
  * **<color #00a2e8>Official Name</color>**: small nuclear ribonucleoprotein U5 subunit 200
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23020|23020]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75643|O75643]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNRNP200&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNRNP200|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601664|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|ResIII|
|Sec63|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)|
|cis assembly of pre-catalytic spliceosome|
|spliceosomal conformational changes to generate catalytic conformation|
|post-mRNA release spliceosomal complex|
|U2-type catalytic step 1 spliceosome|
|U5 snRNP|
|U4/U6 x U5 tri-snRNP complex|
|mRNA cis splicing, via spliceosome|
|helicase activity|
|U2-type precatalytic spliceosome|
|spliceosomal complex assembly|
|RNA helicase activity|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|osteoblast differentiation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ossification|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|identical protein binding|
|RNA binding|
|ATP binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.7|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.71|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.73|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.73|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.74|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.78|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.81|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.81|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.85|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.86|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.92|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.92|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.95|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.97|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.99|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.12|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.16|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.22|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.29|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.31|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.39|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.42|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.49|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|3.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.494|
|[[:human genes:p:psmb4|PSMB4]]|0.474|
|[[:human genes:v:vasn|VASN]]|0.466|
|[[:human genes:c:cwc22|CWC22]]|0.452|
|[[:human genes:r:rrp15|RRP15]]|0.448|
|[[:human genes:s:stil|STIL]]|0.442|
|[[:human genes:s:slc4a1|SLC4A1]]|0.431|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.426|
|[[:human genes:p:prpf8|PRPF8]]|0.418|
|[[:human genes:c:chaf1a|CHAF1A]]|0.418|
|[[:human genes:n:nupl1|NUPL1]]|0.413|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.41|
|[[:human genes:h:hap1|HAP1]]|0.409|
|[[:human genes:c:chd4|CHD4]]|0.408|
|[[:human genes:p:psmb3|PSMB3]]|0.408|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.407|
|[[:human genes:p:pola2|POLA2]]|0.407|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.406|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.405|
|[[:human genes:c:c14orf93|C14orf93]]|0.402|
|[[:human genes:a:aamp|AAMP]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 33
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNRNP200 Expression in NALM6 Cells: 9.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>