======= SNRNP70 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNRNP70
  * **<color #00a2e8>Official Name</color>**: small nuclear ribonucleoprotein U1 subunit 70
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6625|6625]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08621|P08621]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNRNP70&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNRNP70|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|U1snRNP70 N|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of chaperone-mediated autophagy|
|negative regulation of protein refolding|
|regulation of protein refolding|
|negative regulation of protein folding|
|U1 snRNA binding|
|regulation of chaperone-mediated autophagy|
|regulation of protein folding|
|U1 snRNP|
|positive regulation of mRNA splicing, via spliceosome|
|positive regulation of mRNA processing|
|positive regulation of RNA splicing|
|positive regulation of mRNA metabolic process|
|regulation of ATPase activity|
|negative regulation of autophagy|
|spliceosomal complex|
|regulation of mRNA splicing, via spliceosome|
|negative regulation of protein catabolic process|
|regulation of RNA splicing|
|regulation of mRNA processing|
|mRNA binding|
|negative regulation of cellular catabolic process|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|regulation of autophagy|
|regulation of protein catabolic process|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|regulation of cellular catabolic process|
|RNA processing|
|regulation of catabolic process|
|negative regulation of protein metabolic process|
|regulation of hydrolase activity|
|RNA binding|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.74|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.03|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.92|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.92|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.87|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.75|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.79|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.8|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.84|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.85|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.87|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.87|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.87|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.9|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.91|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.95|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.95|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.95|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.96|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.97|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.97|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.01|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.01|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.04|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.14|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.15|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.16|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.17|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.19|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.27|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.29|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.37|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.43|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.61|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.64|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.67|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfip11|TFIP11]]|0.52|
|[[:human genes:p:psmb4|PSMB4]]|0.506|
|[[:human genes:r:rbm39|RBM39]]|0.492|
|[[:human genes:c:cln6|CLN6]]|0.489|
|[[:human genes:p:psap|PSAP]]|0.488|
|[[:human genes:p:paf1|PAF1]]|0.478|
|[[:human genes:o:osbp|OSBP]]|0.471|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.47|
|[[:human genes:o:orc6|ORC6]]|0.469|
|[[:human genes:p:psmb3|PSMB3]]|0.462|
|[[:human genes:a:akirin2|AKIRIN2]]|0.459|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.459|
|[[:human genes:s:sf3a3|SF3A3]]|0.457|
|[[:human genes:v:vasn|VASN]]|0.456|
|[[:human genes:n:narfl|NARFL]]|0.456|
|[[:human genes:c:cdc73|CDC73]]|0.455|
|[[:human genes:s:supt5h|SUPT5H]]|0.455|
|[[:human genes:o:orc1|ORC1]]|0.451|
|[[:human genes:s:sf3a2|SF3A2]]|0.446|
|[[:human genes:c:chd4|CHD4]]|0.446|
|[[:human genes:c:cactin|CACTIN]]|0.439|
|[[:human genes:m:mfsd12|MFSD12]]|0.436|
|[[:human genes:s:syt9|SYT9]]|0.434|
|[[:human genes:c:ckap5|CKAP5]]|0.434|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.433|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.432|
|[[:human genes:i:igfn1|IGFN1]]|0.432|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.432|
|[[:human genes:i:ints6|INTS6]]|0.431|
|[[:human genes:p:pola2|POLA2]]|0.429|
|[[:human genes:i:ik|IK]]|0.427|
|[[:human genes:r:rpl14|RPL14]]|0.427|
|[[:human genes:s:slc4a1|SLC4A1]]|0.424|
|[[:human genes:t:tceb3c|TCEB3C]]|0.422|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.42|
|[[:human genes:e:eif4a3|EIF4A3]]|0.42|
|[[:human genes:s:sf3a1|SF3A1]]|0.419|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.419|
|[[:human genes:p:psma6|PSMA6]]|0.418|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.418|
|[[:human genes:t:ticrr|TICRR]]|0.417|
|[[:human genes:w:wdr87|WDR87]]|0.417|
|[[:human genes:c:cdc6|CDC6]]|0.416|
|[[:human genes:k:kctd17|KCTD17]]|0.414|
|[[:human genes:t:taf15|TAF15]]|0.414|
|[[:human genes:e:exd1|EXD1]]|0.414|
|[[:human genes:s:ssh2|SSH2]]|0.411|
|[[:human genes:s:sec13|SEC13]]|0.411|
|[[:human genes:n:nufip2|NUFIP2]]|0.411|
|[[:human genes:p:psmd3|PSMD3]]|0.41|
|[[:human genes:c:cdh24|CDH24]]|0.409|
|[[:human genes:e:exosc6|EXOSC6]]|0.408|
|[[:human genes:i:iscu|ISCU]]|0.408|
|[[:human genes:r:rpl35|RPL35]]|0.407|
|[[:human genes:r:rpl6|RPL6]]|0.406|
|[[:human genes:a:arcn1|ARCN1]]|0.406|
|[[:human genes:r:rbbp5|RBBP5]]|0.405|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.404|
|[[:human genes:c:cacna1a|CACNA1A]]|0.404|
|[[:human genes:m:mt1e|MT1E]]|0.404|
|[[:human genes:c:c14orf93|C14orf93]]|0.403|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.401|
|[[:human genes:t:top1mt|TOP1MT]]|0.401|
|[[:human genes:r:rrn3|RRN3]]|0.401|
|[[:human genes:r:rps2|RPS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 679/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|25/28|
|blood|27/28|
|bone|26/26|
|breast|32/33|
|central nervous system|52/56|
|cervix|2/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|15/21|
|liver|19/20|
|lung|66/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 587
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNRNP70 Expression in NALM6 Cells: 8.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>