======= SNRPD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNRPD3
  * **<color #00a2e8>Official Name</color>**: small nuclear ribonucleoprotein D3 polypeptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6634|6634]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62318|P62318]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNRPD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNRPD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601062|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:18984161}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U7 snRNA binding|
|histone pre-mRNA DCP binding|
|commitment complex|
|U1 snRNP binding|
|pICln-Sm protein complex|
|U7 snRNP|
|U4 snRNP|
|methylosome|
|small nuclear ribonucleoprotein complex|
|SMN-Sm protein complex|
|U5 snRNP|
|U1 snRNP|
|telomerase holoenzyme complex|
|telomerase RNA binding|
|U2 snRNP|
|U12-type spliceosomal complex|
|histone mRNA metabolic process|
|U2-type catalytic step 2 spliceosome|
|U4/U6 x U5 tri-snRNP complex|
|termination of RNA polymerase II transcription|
|spliceosomal snRNP assembly|
|U2-type precatalytic spliceosome|
|DNA-templated transcription, termination|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|import into nucleus|
|protein alkylation|
|protein methylation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|macromolecule methylation|
|nucleocytoplasmic transport|
|nuclear transport|
|nuclear body|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|methylation|
|enzyme binding|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|intracellular transport|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-2.59|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.45|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.2|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.08|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.08|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.04|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.98|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.94|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.93|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 563/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|20/28|
|blood|25/28|
|bone|20/25|
|breast|24/33|
|central nervous system|43/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|12/15|
|kidney|16/21|
|liver|16/20|
|lung|60/75|
|lymphocyte|11/14|
|ovary|23/26|
|pancreas|17/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|22/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 164
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNRPD3 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>