======= SNRPF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNRPF
  * **<color #00a2e8>Official Name</color>**: small nuclear ribonucleoprotein polypeptide F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6636|6636]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62306|P62306]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNRPF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNRPF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603541|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pICln-Sm protein complex|
|U7 snRNP|
|small nucleolar ribonucleoprotein complex|
|U4 snRNP|
|methylosome|
|small nuclear ribonucleoprotein complex|
|SMN-Sm protein complex|
|U1 snRNP|
|U12-type spliceosomal complex|
|histone mRNA metabolic process|
|U2-type catalytic step 2 spliceosome|
|U4/U6 x U5 tri-snRNP complex|
|termination of RNA polymerase II transcription|
|spliceosomal snRNP assembly|
|U2-type precatalytic spliceosome|
|DNA-templated transcription, termination|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|import into nucleus|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|intracellular transport|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.05|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.9|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.87|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.86|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.84|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.82|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.81|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.7|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.73|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.77|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.78|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.8|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.84|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.84|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.85|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.86|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.97|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.98|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.03|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.1|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|2.12|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.12|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.13|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.21|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.29|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.42|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.98|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|3|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|3.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.467|
|[[:human genes:i:ik|IK]]|0.445|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 26
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNRPF Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>