======= SNW1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNW1
  * **<color #00a2e8>Official Name</color>**: SNW domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22938|22938]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13573|Q13573]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNW1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNW1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603055|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:9632709}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SKIP SNW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of vitamin D receptor signaling pathway|
|positive regulation of response to nutrient levels|
|positive regulation of response to extracellular stimulus|
|regulation of vitamin D receptor signaling pathway|
|cyclin/CDK positive transcription elongation factor complex|
|retinoic acid receptor binding|
|vitamin D receptor binding|
|retinoic acid receptor signaling pathway|
|regulation of retinoic acid receptor signaling pathway|
|positive regulation of histone H3-K4 methylation|
|positive regulation by host of viral transcription|
|positive regulation of transcription of Notch receptor target|
|positive regulation of mRNA splicing, via spliceosome|
|regulation of response to nutrient levels|
|regulation of response to extracellular stimulus|
|nuclear hormone receptor binding|
|Notch binding|
|regulation of histone H3-K4 methylation|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|U2-type catalytic step 2 spliceosome|
|positive regulation of mRNA processing|
|positive regulation of RNA splicing|
|positive regulation of histone methylation|
|positive regulation of viral transcription|
|androgen receptor binding|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|positive regulation of Notch signaling pathway|
|SMAD binding|
|regulation of viral transcription|
|regulation of histone methylation|
|cellular response to retinoic acid|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|positive regulation of mRNA metabolic process|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|positive regulation of histone modification|
|regulation of mRNA splicing, via spliceosome|
|regulation of Notch signaling pathway|
|positive regulation of chromatin organization|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of viral process|
|response to retinoic acid|
|nuclear matrix|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|signal transduction by p53 class mediator|
|Notch signaling pathway|
|regulation of RNA splicing|
|regulation of mRNA processing|
|regulation of histone modification|
|intrinsic apoptotic signaling pathway|
|modification of morphology or physiology of other organism|
|intracellular receptor signaling pathway|
|positive regulation of chromosome organization|
|transcription initiation from RNA polymerase II promoter|
|regulation of chromatin organization|
|regulation of viral process|
|cellular response to acid chemical|
|DNA-templated transcription, initiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|transcription corepressor activity|
|regulation of cellular response to growth factor stimulus|
|nuclear body|
|apoptotic signaling pathway|
|transcription coactivator activity|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|response to acid chemical|
|enzyme binding|
|regulation of chromosome organization|
|RNA splicing|
|nuclear speck|
|positive regulation of neurogenesis|
|mRNA processing|
|transcription by RNA polymerase II|
|positive regulation of multi-organism process|
|cellular response to lipid|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|viral process|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.82|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 719/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|13/15|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2636
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNW1 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>