======= SNX9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNX9
  * **<color #00a2e8>Official Name</color>**: sorting nexin 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51429|51429]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5X1|Q9Y5X1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNX9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNX9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605952|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PX|
|BAR 3 WASP bdg|
|SH3 1|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipid tube assembly|
|cleavage furrow formation|
|cuticular plate|
|Arp2/3 complex binding|
|positive regulation of membrane protein ectodomain proteolysis|
|1-phosphatidylinositol binding|
|plasma membrane tubulation|
|regulation of membrane protein ectodomain proteolysis|
|positive regulation of protein oligomerization|
|protein-lipid complex assembly|
|cytokinetic process|
|regulation of protein oligomerization|
|protein-lipid complex subunit organization|
|clathrin-coated vesicle|
|extrinsic component of cytoplasmic side of plasma membrane|
|mitotic cytokinesis|
|phosphatidylinositol binding|
|positive regulation of actin filament polymerization|
|plasma membrane organization|
|ruffle|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|positive regulation of protein polymerization|
|plasma membrane invagination|
|cytoplasmic vesicle membrane|
|membrane invagination|
|regulation of actin filament polymerization|
|trans-Golgi network|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|positive regulation of protein catabolic process|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|endosomal transport|
|receptor-mediated endocytosis|
|positive regulation of protein complex assembly|
|cytoplasmic vesicle|
|regulation of actin filament organization|
|ubiquitin protein ligase binding|
|cadherin binding|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of cellular component size|
|regulation of protein catabolic process|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|endomembrane system organization|
|positive regulation of catabolic process|
|regulation of protein complex assembly|
|regulation of GTPase activity|
|cell division|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|endocytosis|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|import into cell|
|mitotic cell cycle|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|intracellular protein transport|
|regulation of catabolic process|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|identical protein binding|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.24|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.01|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.97|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.82|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15831
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNX9 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>