======= SOCS5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOCS5
  * **<color #00a2e8>Official Name</color>**: suppressor of cytokine signaling 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9655|9655]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75159|O75159]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOCS5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOCS5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607094|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269|PubMed:15590694}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SOCS box|
|SOCS|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vascular endothelial cell response to fluid shear stress|
|negative regulation of T-helper 2 cell differentiation|
|negative regulation of monocyte chemotactic protein-1 production|
|positive regulation of T-helper 1 cell differentiation|
|regulation of T-helper 1 cell differentiation|
|regulation of T-helper 2 cell differentiation|
|negative regulation of type 2 immune response|
|1-phosphatidylinositol-3-kinase regulator activity|
|negative regulation of epidermal growth factor-activated receptor activity|
|negative regulation of T-helper cell differentiation|
|regulation of monocyte chemotactic protein-1 production|
|cellular response to low-density lipoprotein particle stimulus|
|cellular response to fluid shear stress|
|negative regulation of chemokine production|
|phosphatidylinositol 3-kinase complex|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of T-helper 1 type immune response|
|positive regulation of T-helper cell differentiation|
|negative regulation of alpha-beta T cell differentiation|
|response to lipoprotein particle|
|regulation of T-helper 1 type immune response|
|regulation of epidermal growth factor-activated receptor activity|
|negative regulation of protein tyrosine kinase activity|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|cellular response to lipoprotein particle stimulus|
|regulation of type 2 immune response|
|epidermal growth factor receptor binding|
|regulation of T-helper cell differentiation|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|response to fluid shear stress|
|negative regulation of alpha-beta T cell activation|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|negative regulation of T cell differentiation|
|negative regulation of interleukin-6 production|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|negative regulation of epidermal growth factor receptor signaling pathway|
|epidermal growth factor receptor signaling pathway|
|negative regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of ERBB signaling pathway|
|phosphatidylinositol phosphorylation|
|negative regulation of lymphocyte differentiation|
|regulation of phosphatidylinositol 3-kinase activity|
|receptor tyrosine kinase binding|
|negative regulation of signaling receptor activity|
|regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|regulation of lipid kinase activity|
|lipid phosphorylation|
|ERBB signaling pathway|
|regulation of chemokine production|
|positive regulation of T cell differentiation|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of phospholipid metabolic process|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of leukocyte differentiation|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of adaptive immune response|
|negative regulation of T cell activation|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of inflammatory response|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|regulation of interleukin-6 production|
|positive regulation of cellular protein catabolic process|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of adaptive immune response|
|phosphatidylinositol metabolic process|
|regulation of lymphocyte differentiation|
|regulation of signaling receptor activity|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|regulation of proteasomal protein catabolic process|
|positive regulation of hemopoiesis|
|negative regulation of cell activation|
|lipid modification|
|positive regulation of T cell activation|
|negative regulation of defense response|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of immune effector process|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|regulation of cellular protein catabolic process|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|negative regulation of transferase activity|
|regulation of leukocyte cell-cell adhesion|
|glycerophospholipid metabolic process|
|regulation of T cell activation|
|regulation of inflammatory response|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|negative regulation of response to external stimulus|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of protein catabolic process|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|positive regulation of cell activation|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|regulation of immune effector process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of growth|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|protein ubiquitination|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of defense response|
|protein modification by small protein conjugation|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|regulation of kinase activity|
|organophosphate metabolic process|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14070
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOCS5 Expression in NALM6 Cells: 4.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>