======= SON =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SON
  * **<color #00a2e8>Official Name</color>**: SON DNA and RNA binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6651|6651]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18583|P18583]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SON&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SON|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182465|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-patch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RS domain binding|
|mitotic cytokinesis|
|cytoskeleton-dependent cytokinesis|
|regulation of mRNA splicing, via spliceosome|
|cytokinesis|
|regulation of RNA splicing|
|regulation of mRNA processing|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|microtubule cytoskeleton organization|
|mRNA processing|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|mRNA metabolic process|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|cell cycle process|
|cytoskeleton organization|
|regulation of cell cycle|
|cell cycle|
|RNA binding|
|DNA binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|RNA metabolic process|
|regulation of cell death|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.19|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.85|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.84|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.7|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.71|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.73|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.74|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.78|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.79|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.85|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.87|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.93|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.94|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.94|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.97|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.11|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.14|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.22|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.23|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.31|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.32|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.33|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:memo1|MEMO1]]|0.424|
|[[:human genes:s:sf3a2|SF3A2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 572/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|24/28|
|blood|24/28|
|bone|19/26|
|breast|29/33|
|central nervous system|39/56|
|cervix|1/4|
|colorectal|13/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|15/21|
|liver|12/20|
|lung|59/75|
|lymphocyte|12/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|10/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 572
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SON Expression in NALM6 Cells: 9.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>