======= SORD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SORD
  * **<color #00a2e8>Official Name</color>**: sorbitol dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6652|6652]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00796|Q00796]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SORD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SORD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182500|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. {ECO:0000250|UniProtKB:Q64442, ECO:0000269|PubMed:16278369}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADH N|
|ADH zinc N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-xylitol metabolic process|
|pentitol catabolic process|
|sorbitol catabolic process|
|(R,R)-butanediol dehydrogenase activity|
|D-xylulose reductase activity|
|L-iditol 2-dehydrogenase activity|
|ribitol 2-dehydrogenase activity|
|L-xylitol catabolic process|
|hexitol catabolic process|
|pentitol metabolic process|
|sorbitol metabolic process|
|fructose biosynthetic process|
|hexitol metabolic process|
|xylulose 5-phosphate biosynthetic process|
|glucuronate catabolic process|
|xylulose 5-phosphate metabolic process|
|glucuronate catabolic process to xylulose 5-phosphate|
|alditol catabolic process|
|fructose metabolic process|
|glucuronate metabolic process|
|uronic acid metabolic process|
|alditol metabolic process|
|polyol catabolic process|
|cellular carbohydrate catabolic process|
|NAD binding|
|response to copper ion|
|hexose biosynthetic process|
|monosaccharide biosynthetic process|
|alcohol catabolic process|
|monosaccharide catabolic process|
|response to cadmium ion|
|flagellated sperm motility|
|sperm motility|
|organic hydroxy compound catabolic process|
|response to osmotic stress|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|motile cilium|
|mitochondrial membrane|
|polyol metabolic process|
|glucose metabolic process|
|monocarboxylic acid catabolic process|
|carbohydrate catabolic process|
|carbohydrate biosynthetic process|
|hexose metabolic process|
|cellular carbohydrate metabolic process|
|carbohydrate binding|
|monosaccharide metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|alcohol metabolic process|
|response to metal ion|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|response to nutrient levels|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|response to inorganic substance|
|organophosphate biosynthetic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|zinc ion binding|
|organophosphate metabolic process|
|response to hormone|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|cell motility|
|localization of cell|
|response to abiotic stimulus|
|locomotion|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|extracellular space|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SORD Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>