======= SORT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SORT1
  * **<color #00a2e8>Official Name</color>**: sortilin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6272|6272]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99523|Q99523]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SORT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SORT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602458|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125, ECO:0000269|PubMed:11331584, ECO:0000269|PubMed:11390366, ECO:0000269|PubMed:12209882, ECO:0000269|PubMed:12598608, ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:14985763, ECO:0000269|PubMed:15313463, ECO:0000269|PubMed:15930396, ECO:0000269|PubMed:15987945}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotensin receptor activity, non-G protein-coupled|
|nerve growth factor receptor activity|
|nerve growth factor binding|
|negative regulation of lipoprotein lipase activity|
|plasma membrane to endosome transport|
|glucose import|
|nerve growth factor signaling pathway|
|trans-Golgi network transport vesicle|
|negative regulation of lipase activity|
|Golgi to endosome transport|
|neurotrophin TRK receptor signaling pathway|
|regulation of lipoprotein lipase activity|
|endosome transport via multivesicular body sorting pathway|
|neurotrophin signaling pathway|
|glucose transmembrane transport|
|positive regulation of epithelial cell apoptotic process|
|extrinsic apoptotic signaling pathway via death domain receptors|
|multivesicular body sorting pathway|
|hexose transmembrane transport|
|monosaccharide transmembrane transport|
|carbohydrate transmembrane transport|
|negative regulation of fat cell differentiation|
|cellular response to nerve growth factor stimulus|
|response to nerve growth factor|
|endosome to lysosome transport|
|clathrin-coated pit|
|clathrin-coated vesicle|
|myotube differentiation|
|carbohydrate transport|
|regulation of epithelial cell apoptotic process|
|Golgi cisterna membrane|
|extrinsic apoptotic signaling pathway|
|regulation of lipase activity|
|post-Golgi vesicle-mediated transport|
|lysosomal transport|
|neuropeptide signaling pathway|
|regulation of fat cell differentiation|
|vacuolar transport|
|cytoplasmic vesicle membrane|
|cytosolic transport|
|striated muscle cell differentiation|
|endosome membrane|
|response to insulin|
|endosomal transport|
|nuclear membrane|
|muscle cell differentiation|
|lysosome|
|cytoplasmic vesicle|
|early endosome|
|ossification|
|apoptotic signaling pathway|
|lysosomal membrane|
|vesicle organization|
|enzyme binding|
|neuronal cell body|
|Golgi vesicle transport|
|response to peptide hormone|
|dendrite|
|negative regulation of hydrolase activity|
|response to peptide|
|muscle structure development|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|endocytosis|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|import into cell|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|negative regulation of catalytic activity|
|response to hormone|
|apoptotic process|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|Golgi apparatus|
|response to organonitrogen compound|
|programmed cell death|
|response to nitrogen compound|
|cell death|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|transmembrane transport|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|intracellular transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell death|
|regulation of cell differentiation|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10474
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SORT1 Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>