======= SOS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOS1
  * **<color #00a2e8>Official Name</color>**: SOS Ras/Rac guanine nucleotide exchange factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6654|6654]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07889|Q07889]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182530|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RasGEF N|
|Histone|
|RhoGEF|
|RasGEF|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|midbrain morphogenesis|
|vitellogenesis|
|regulation of pro-B cell differentiation|
|regulation of lymphoid progenitor cell differentiation|
|pericardium morphogenesis|
|cytoplasm organization|
|eyelid development in camera-type eye|
|Ras guanyl-nucleotide exchange factor activity|
|pericardium development|
|neurotrophin TRK receptor signaling pathway|
|regulation of T cell differentiation in thymus|
|B cell homeostasis|
|neurotrophin signaling pathway|
|cardiac atrium morphogenesis|
|positive regulation of epidermal growth factor receptor signaling pathway|
|heart trabecula morphogenesis|
|ERBB2 signaling pathway|
|brain morphogenesis|
|positive regulation of ERBB signaling pathway|
|cardiac atrium development|
|trabecula morphogenesis|
|morphogenesis of an epithelial sheet|
|epidermal growth factor receptor signaling pathway|
|lymphocyte homeostasis|
|nucleosome|
|leukocyte homeostasis|
|ERBB signaling pathway|
|Rho guanyl-nucleotide exchange factor activity|
|hair follicle development|
|positive regulation of small GTPase mediated signal transduction|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|multicellular organism growth|
|regulation of epidermal growth factor receptor signaling pathway|
|midbrain development|
|regulation of hematopoietic progenitor cell differentiation|
|insulin receptor signaling pathway|
|roof of mouth development|
|regulation of ERBB signaling pathway|
|molting cycle|
|hair cycle|
|guanyl-nucleotide exchange factor activity|
|cardiac chamber morphogenesis|
|female gamete generation|
|SH3 domain binding|
|regulation of T cell differentiation|
|regulation of Rho protein signal transduction|
|regulation of T cell proliferation|
|cellular response to insulin stimulus|
|regulation of lymphocyte differentiation|
|cardiac chamber development|
|Fc-epsilon receptor signaling pathway|
|homeostasis of number of cells|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|response to insulin|
|Fc receptor signaling pathway|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|heart morphogenesis|
|postsynaptic density|
|axon guidance|
|neuron projection guidance|
|cellular response to peptide hormone stimulus|
|regulation of leukocyte differentiation|
|GTPase activator activity|
|camera-type eye development|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|cellular response to peptide|
|regulation of small GTPase mediated signal transduction|
|cellular process involved in reproduction in multicellular organism|
|eye development|
|visual system development|
|sensory system development|
|axonogenesis|
|MAPK cascade|
|neuronal cell body|
|leukocyte migration|
|skin development|
|developmental growth|
|response to peptide hormone|
|growth|
|signal transduction by protein phosphorylation|
|blood vessel morphogenesis|
|axon development|
|positive regulation of GTPase activity|
|epidermis development|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|regulation of hemopoiesis|
|response to peptide|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|protein heterodimerization activity|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|cardiovascular system development|
|heart development|
|response to growth factor|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|cellular response to nitrogen compound|
|neuron projection development|
|cytokine-mediated signaling pathway|
|gamete generation|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|positive regulation of hydrolase activity|
|head development|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|circulatory system development|
|response to hormone|
|animal organ morphogenesis|
|cell migration|
|protein phosphorylation|
|embryo development|
|central nervous system development|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|response to cytokine|
|epithelium development|
|plasma membrane bounded cell projection organization|
|regulation of immune response|
|cell projection organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|G protein-coupled receptor signaling pathway|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|DNA binding|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-2.05|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.81|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 16/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|10/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15360
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOS1 Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>