======= SOX11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOX11
  * **<color #00a2e8>Official Name</color>**: SRY-box transcription factor 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6664|6664]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35716|P35716]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOX11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOX11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600898|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development. {ECO:0000269|PubMed:24886874}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|closure of optic fissure|
|regulation of lens epithelial cell proliferation|
|positive regulation of lens epithelial cell proliferation|
|positive regulation of hippo signaling|
|soft palate development|
|hard palate development|
|noradrenergic neuron differentiation|
|optic cup morphogenesis involved in camera-type eye development|
|cornea development in camera-type eye|
|cardiac ventricle formation|
|limb bud formation|
|cardiac chamber formation|
|regulation of hippo signaling|
|embryonic camera-type eye formation|
|eyelid development in camera-type eye|
|negative regulation of glial cell proliferation|
|glial cell proliferation|
|embryonic digestive tract morphogenesis|
|sympathetic nervous system development|
|negative regulation of transcription regulatory region DNA binding|
|lens morphogenesis in camera-type eye|
|secondary palate development|
|enhancer sequence-specific DNA binding|
|nuclear transcription factor complex|
|embryonic camera-type eye morphogenesis|
|regulation of glial cell proliferation|
|positive regulation of BMP signaling pathway|
|embryonic eye morphogenesis|
|embryonic digestive tract development|
|embryonic camera-type eye development|
|positive regulation of stem cell proliferation|
|negative regulation of gliogenesis|
|ventricular septum morphogenesis|
|oligodendrocyte development|
|lung morphogenesis|
|neuroepithelial cell differentiation|
|autonomic nervous system development|
|digestive tract morphogenesis|
|morphogenesis of an epithelial sheet|
|skeletal muscle cell differentiation|
|regulation of transcription regulatory region DNA binding|
|negative regulation of DNA binding|
|positive regulation of osteoblast differentiation|
|regulation of stem cell proliferation|
|oligodendrocyte differentiation|
|ventricular septum development|
|signal transduction involved in cell cycle checkpoint|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|cardiac ventricle morphogenesis|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|transcription regulatory region sequence-specific DNA binding|
|lens development in camera-type eye|
|neural crest cell development|
|negative regulation of leukocyte proliferation|
|somite development|
|mesenchymal cell development|
|stem cell development|
|positive regulation of ossification|
|regulation of BMP signaling pathway|
|neural crest cell differentiation|
|roof of mouth development|
|embryonic skeletal system morphogenesis|
|columnar/cuboidal epithelial cell differentiation|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|neural tube formation|
|spinal cord development|
|glial cell development|
|cardiac septum development|
|regulation of osteoblast differentiation|
|camera-type eye morphogenesis|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|regulation of gliogenesis|
|skeletal muscle tissue development|
|embryonic epithelial tube formation|
|regulation of DNA binding|
|embryonic skeletal system development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|positive regulation of hormone secretion|
|digestive tract development|
|epithelial tube formation|
|skeletal muscle organ development|
|digestive system development|
|morphogenesis of embryonic epithelium|
|negative regulation of lymphocyte activation|
|eye morphogenesis|
|tube formation|
|limb morphogenesis|
|appendage morphogenesis|
|mesenchymal cell differentiation|
|stem cell differentiation|
|neural tube development|
|lung development|
|negative regulation of binding|
|cardiac chamber development|
|glial cell differentiation|
|respiratory tube development|
|negative regulation of leukocyte activation|
|limb development|
|appendage development|
|positive regulation of epithelial cell proliferation|
|regulation of ossification|
|cell cycle checkpoint|
|respiratory system development|
|negative regulation of cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|gliogenesis|
|mesenchyme development|
|regulation of leukocyte proliferation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|heart morphogenesis|
|sensory organ morphogenesis|
|kidney development|
|regulation of hormone secretion|
|regulation of cellular response to growth factor stimulus|
|striated muscle tissue development|
|renal system development|
|transcription coactivator activity|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|urogenital system development|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|eye development|
|visual system development|
|positive regulation of neuron differentiation|
|sensory system development|
|regulation of binding|
|positive regulation of secretion by cell|
|morphogenesis of an epithelium|
|embryonic organ development|
|positive regulation of secretion|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of neurogenesis|
|muscle structure development|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of lymphocyte activation|
|heart development|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|regulation of leukocyte activation|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of neurogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|positive regulation of transport|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|epithelium development|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7702
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOX11 Expression in NALM6 Cells: 0.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>