======= SOX12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOX12
  * **<color #00a2e8>Official Name</color>**: SRY-box transcription factor 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6666|6666]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15370|O15370]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOX12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOX12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601947|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the sequence 5'-AACAAT-3'. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear transcription factor complex|
|protein-DNA complex|
|transcription regulatory region sequence-specific DNA binding|
|spinal cord development|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|cell fate commitment|
|transcription coactivator activity|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|cellular protein-containing complex assembly|
|central nervous system development|
|positive regulation of transcription by RNA polymerase II|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.35|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.98|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.75|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.75|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.76|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.77|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.79|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.96|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.01|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.07|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.15|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15950
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOX12 Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>