======= SP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SP3
  * **<color #00a2e8>Official Name</color>**: Sp3 transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6670|6670]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02447|Q02447]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601804|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|embryonic process involved in female pregnancy|
|enucleate erythrocyte differentiation|
|natural killer cell differentiation|
|trophectodermal cell differentiation|
|definitive hemopoiesis|
|monocyte differentiation|
|mononuclear cell differentiation|
|granulocyte differentiation|
|megakaryocyte differentiation|
|embryonic camera-type eye morphogenesis|
|proximal promoter sequence-specific DNA binding|
|embryonic eye morphogenesis|
|embryonic camera-type eye development|
|blastocyst formation|
|protein-DNA complex|
|transcriptional repressor complex|
|natural killer cell activation|
|erythrocyte differentiation|
|embryonic placenta development|
|erythrocyte homeostasis|
|blastocyst development|
|PML body|
|myeloid cell homeostasis|
|B cell differentiation|
|myeloid leukocyte differentiation|
|camera-type eye morphogenesis|
|liver development|
|embryonic skeletal system development|
|hepaticobiliary system development|
|T cell differentiation|
|eye morphogenesis|
|placenta development|
|B cell activation|
|lung development|
|respiratory tube development|
|female pregnancy|
|respiratory system development|
|homeostasis of number of cells|
|multi-multicellular organism process|
|myeloid cell differentiation|
|T cell activation|
|lymphocyte differentiation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|sensory organ morphogenesis|
|ossification|
|embryonic organ morphogenesis|
|camera-type eye development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|leukocyte differentiation|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|lymphocyte activation|
|chromatin binding|
|gland development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|sensory organ development|
|hemopoiesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|animal organ morphogenesis|
|embryo development|
|multi-organism reproductive process|
|cell activation|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.16|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.89|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.82|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.75|
|[[:results:exp453|B02 10μM R08 exp453]]|1.72|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.72|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.75|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.84|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.88|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.89|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.95|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.95|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.98|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.02|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.47|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.87|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.96|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.19|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fbxo11|FBXO11]]|0.543|
|[[:human genes:t:tp53|TP53]]|0.506|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.45|
|[[:human genes:z:znf592|ZNF592]]|0.44|
|[[:human genes:u:ube3a|UBE3A]]|0.425|
|[[:human genes:m:med23|MED23]]|0.42|
|[[:human genes:a:actb|ACTB]]|0.417|
|[[:human genes:b:bap1|BAP1]]|0.402|
|[[:human genes:i:id3|ID3]]|0.4|
|[[:human genes:f:fkbp5|FKBP5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2691
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SP3 Expression in NALM6 Cells: 7.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>