======= SPCS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPCS3
  * **<color #00a2e8>Official Name</color>**: signal peptidase complex subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60559|60559]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61009|P61009]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPCS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPCS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618854|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000269|PubMed:27499293}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPC22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signal peptidase complex|
|signal peptide processing|
|peptidase activity|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein processing|
|protein maturation|
|protein targeting|
|establishment of protein localization to organelle|
|peptide metabolic process|
|protein localization to organelle|
|cellular amide metabolic process|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|endoplasmic reticulum|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.74|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.599|
|[[:human genes:h:hspd1|HSPD1]]|0.517|
|[[:human genes:s:slc35b1|SLC35B1]]|0.513|
|[[:human genes:n:nars|NARS]]|0.51|
|[[:human genes:a:aars|AARS]]|0.5|
|[[:human genes:d:dhdds|DHDDS]]|0.493|
|[[:human genes:c:ccdc101|CCDC101]]|0.486|
|[[:human genes:m:mtor|MTOR]]|0.465|
|[[:human genes:m:med23|MED23]]|0.462|
|[[:human genes:t:tti2|TTI2]]|0.462|
|[[:human genes:r:rnmt|RNMT]]|0.462|
|[[:human genes:m:mars|MARS]]|0.458|
|[[:human genes:z:znf259|ZNF259]]|0.456|
|[[:human genes:g:gfpt1|GFPT1]]|0.454|
|[[:human genes:p:pelo|PELO]]|0.45|
|[[:human genes:d:dad1|DAD1]]|0.449|
|[[:human genes:g:gmppb|GMPPB]]|0.447|
|[[:human genes:e:eif4e|EIF4E]]|0.446|
|[[:human genes:m:med16|MED16]]|0.445|
|[[:human genes:g:gnb1l|GNB1L]]|0.442|
|[[:human genes:c:cars|CARS]]|0.435|
|[[:human genes:x:xpo5|XPO5]]|0.432|
|[[:human genes:u:uap1|UAP1]]|0.431|
|[[:human genes:n:nae1|NAE1]]|0.426|
|[[:human genes:p:polr3b|POLR3B]]|0.426|
|[[:human genes:y:yars|YARS]]|0.426|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.424|
|[[:human genes:a:abcb7|ABCB7]]|0.417|
|[[:human genes:p:pam16|PAM16]]|0.417|
|[[:human genes:v:vrk1|VRK1]]|0.416|
|[[:human genes:d:dhps|DHPS]]|0.414|
|[[:human genes:s:srp68|SRP68]]|0.413|
|[[:human genes:d:dpagt1|DPAGT1]]|0.411|
|[[:human genes:r:rptor|RPTOR]]|0.407|
|[[:human genes:d:dkc1|DKC1]]|0.405|
|[[:human genes:d:dicer1|DICER1]]|0.404|
|[[:human genes:t:txnl4b|TXNL4B]]|0.403|
|[[:human genes:a:alg2|ALG2]]|0.401|
|[[:human genes:a:alg1|ALG1]]|0.401|
|[[:human genes:c:cct7|CCT7]]|0.4|
|[[:human genes:c:csnk2b|CSNK2B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 338/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|10/28|
|bone|15/26|
|breast|13/33|
|central nervous system|37/56|
|cervix|2/4|
|colorectal|10/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|9/21|
|liver|10/20|
|lung|33/75|
|lymphocyte|7/16|
|ovary|8/26|
|pancreas|6/24|
|peripheral nervous system|6/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|6/22|
|urinary tract|14/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1685
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPCS3 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>