======= SPHK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPHK1
  * **<color #00a2e8>Official Name</color>**: sphingosine kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8877|8877]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYA1|Q9NYA1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPHK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPHK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N- dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. {ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:23602659}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAGK cat|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sphingoid catabolic process|
|regulation of endosomal vesicle fusion|
|sphinganine kinase activity|
|D-erythro-sphingosine kinase activity|
|negative regulation of sphingolipid biosynthetic process|
|negative regulation of ceramide biosynthetic process|
|sphingosine-1-phosphate receptor activity|
|sphingosine-1-phosphate receptor signaling pathway|
|sphingolipid mediated signaling pathway|
|sphingosine biosynthetic process|
|sphingoid biosynthetic process|
|sphingosine metabolic process|
|regulation of ceramide biosynthetic process|
|regulation of membrane lipid metabolic process|
|sphingoid metabolic process|
|regulation of sphingolipid biosynthetic process|
|NAD+ kinase activity|
|regulation of microglial cell activation|
|positive regulation of interleukin-17 production|
|diol biosynthetic process|
|acetyltransferase activity|
|diol metabolic process|
|positive regulation of p38MAPK cascade|
|regulation of interleukin-17 production|
|positive regulation of peptidyl-threonine phosphorylation|
|regulation of vesicle fusion|
|positive regulation of smooth muscle contraction|
|regulation of neuroinflammatory response|
|sphingolipid catabolic process|
|protein phosphatase 2A binding|
|membrane lipid catabolic process|
|cellular response to vascular endothelial growth factor stimulus|
|regulation of p38MAPK cascade|
|regulation of peptidyl-threonine phosphorylation|
|positive regulation of muscle contraction|
|negative regulation of lipid biosynthetic process|
|positive regulation of fibroblast proliferation|
|regulation of macrophage activation|
|positive regulation of mitotic nuclear division|
|clathrin-coated pit|
|regulation of tumor necrosis factor-mediated signaling pathway|
|endocytic vesicle|
|polyol biosynthetic process|
|regulation of smooth muscle contraction|
|lipid phosphorylation|
|positive regulation of nuclear division|
|cellular response to hydrogen peroxide|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of fibroblast proliferation|
|regulation of interleukin-1 beta production|
|negative regulation of lipid metabolic process|
|sphingolipid biosynthetic process|
|regulation of interleukin-1 production|
|presynapse|
|regulation of phagocytosis|
|regulation of NIK/NF-kappaB signaling|
|DNA biosynthetic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|positive regulation of protein ubiquitination|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|membrane lipid biosynthetic process|
|cellular response to reactive oxygen species|
|positive regulation of protein modification by small protein conjugation or removal|
|protein acetylation|
|calcium-mediated signaling|
|negative regulation of cellular amide metabolic process|
|positive regulation of mitotic cell cycle|
|positive regulation of NF-kappaB transcription factor activity|
|early endosome membrane|
|sphingolipid metabolic process|
|lipid binding|
|regulation of muscle contraction|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of angiogenesis|
|positive regulation of cell growth|
|positive regulation of stress-activated MAPK cascade|
|regulation of mitotic nuclear division|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of response to cytokine stimulus|
|positive regulation of vasculature development|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|protein acylation|
|regulation of nuclear division|
|ammonium ion metabolic process|
|response to reactive oxygen species|
|cellular lipid catabolic process|
|regulation of protein ubiquitination|
|lipid modification|
|calmodulin binding|
|membrane lipid metabolic process|
|regulation of endocytosis|
|cellular response to toxic substance|
|magnesium ion binding|
|regulation of protein modification by small protein conjugation or removal|
|protein folding|
|regulation of stress-activated MAPK cascade|
|regulation of muscle system process|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to oxidative stress|
|positive regulation of growth|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|lipid catabolic process|
|response to antibiotic|
|alcohol metabolic process|
|regulation of vasculature development|
|second-messenger-mediated signaling|
|regulation of inflammatory response|
|positive regulation of cell cycle|
|response to oxidative stress|
|regulation of lipid metabolic process|
|cellular response to drug|
|regulation of cellular amide metabolic process|
|regulation of cell growth|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cytokine production|
|organic hydroxy compound metabolic process|
|blood vessel development|
|inflammatory response|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|response to toxic substance|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|response to inorganic substance|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|cell junction|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|lipid biosynthetic process|
|regulation of system process|
|small molecule biosynthetic process|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|regulation of growth|
|regulation of cytokine production|
|regulation of cellular response to stress|
|brain development|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of defense response|
|head development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|central nervous system development|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|defense response|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|DNA binding|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11766
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPHK1 Expression in NALM6 Cells: 0.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>