======= SPIRE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPIRE2
  * **<color #00a2e8>Official Name</color>**: spire type actin nucleation factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84501|84501]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WWL2|Q8WWL2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPIRE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPIRE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609217|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269|PubMed:21620703}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|formin-nucleated actin cable organization|
|formin-nucleated actin cable assembly|
|polar body extrusion after meiotic divisions|
|establishment of meiotic spindle localization|
|meiotic cytokinesis|
|parallel actin filament bundle assembly|
|cleavage furrow formation|
|positive regulation of double-strand break repair|
|female meiotic nuclear division|
|actin nucleation|
|cytokinetic process|
|establishment of spindle localization|
|spindle localization|
|cleavage furrow|
|actin filament bundle assembly|
|positive regulation of DNA repair|
|actin filament bundle organization|
|regulation of double-strand break repair|
|positive regulation of actin filament polymerization|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|positive regulation of response to DNA damage stimulus|
|regulation of DNA repair|
|positive regulation of protein polymerization|
|female gamete generation|
|cell cortex|
|plasma membrane invagination|
|cytoplasmic vesicle membrane|
|membrane invagination|
|meiotic nuclear division|
|regulation of actin filament polymerization|
|meiotic cell cycle process|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of DNA metabolic process|
|positive regulation of supramolecular fiber organization|
|regulation of response to DNA damage stimulus|
|positive regulation of cytoskeleton organization|
|meiotic cell cycle|
|regulation of protein polymerization|
|actin filament organization|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|actin binding|
|nuclear division|
|organelle fission|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of DNA metabolic process|
|cellular process involved in reproduction in multicellular organism|
|establishment of organelle localization|
|cytoskeleton|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|cell division|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|actin filament-based process|
|organelle localization|
|positive regulation of organelle organization|
|microtubule-based process|
|gamete generation|
|regulation of cellular response to stress|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|regulation of cellular component biogenesis|
|multi-organism reproductive process|
|cell cycle process|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.88|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.78|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.72|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5996
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPIRE2 Expression in NALM6 Cells: 4.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>