======= SPR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPR
  * **<color #00a2e8>Official Name</color>**: sepiapterin reductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6697|6697]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35270|P35270]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182125|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|adh short|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sepiapterin reductase activity|
|tetrahydrobiopterin metabolic process|
|tetrahydrobiopterin biosynthetic process|
|aldo-keto reductase (NADP) activity|
|nitric oxide biosynthetic process|
|pteridine-containing compound biosynthetic process|
|nitric oxide metabolic process|
|diol biosynthetic process|
|reactive nitrogen species metabolic process|
|diol metabolic process|
|reactive oxygen species biosynthetic process|
|pteridine-containing compound metabolic process|
|NADP binding|
|neurotransmitter biosynthetic process|
|regulation of nitric-oxide synthase activity|
|regulation of monooxygenase activity|
|polyol biosynthetic process|
|neurotransmitter metabolic process|
|regulation of oxidoreductase activity|
|polyol metabolic process|
|reactive oxygen species metabolic process|
|alcohol biosynthetic process|
|coenzyme biosynthetic process|
|organic hydroxy compound biosynthetic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|alcohol metabolic process|
|regulation of neurotransmitter levels|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|small molecule biosynthetic process|
|oxidation-reduction process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-3.14|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.95|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.27|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.07|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.05|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.91|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.89|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.89|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.85|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.83|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.81|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.8|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.79|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.75|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.71|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.72|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.76|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.76|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.77|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.82|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.84|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pts|PTS]]|0.499|
|[[:human genes:d:dhrsx|DHRSX]]|0.465|
|[[:human genes:r:rnaseh2b|RNASEH2B]]|0.464|
|[[:human genes:r:rpp21|RPP21]]|0.45|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.449|
|[[:human genes:r:rabggtb|RABGGTB]]|0.43|
|[[:human genes:a:alg1|ALG1]]|0.428|
|[[:human genes:t:txnl4b|TXNL4B]]|0.422|
|[[:human genes:t:thg1l|THG1L]]|0.414|
|[[:human genes:v:vezt|VEZT]]|0.414|
|[[:human genes:p:ppp6c|PPP6C]]|0.412|
|[[:human genes:r:rnaseh2a|RNASEH2A]]|0.411|
|[[:human genes:k:kdsr|KDSR]]|0.41|
|[[:human genes:w:wdr1|WDR1]]|0.409|
|[[:human genes:r:rad1|RAD1]]|0.409|
|[[:human genes:r:rpe|RPE]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7721
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPR Expression in NALM6 Cells: 3.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>