======= SPTLC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPTLC2
  * **<color #00a2e8>Official Name</color>**: serine palmitoyltransferase long chain base subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9517|9517]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15270|O15270]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPTLC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPTLC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605713|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. {ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:20920666}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aminotran 1 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sphinganine biosynthetic process|
|sphinganine metabolic process|
|serine C-palmitoyltransferase complex|
|positive regulation of lipophagy|
|serine C-palmitoyltransferase activity|
|regulation of lipophagy|
|sphingomyelin biosynthetic process|
|sphingosine biosynthetic process|
|sphingoid biosynthetic process|
|sphingosine metabolic process|
|sphingomyelin metabolic process|
|sphingoid metabolic process|
|diol biosynthetic process|
|diol metabolic process|
|adipose tissue development|
|ceramide biosynthetic process|
|pyridoxal phosphate binding|
|polyol biosynthetic process|
|positive regulation of macroautophagy|
|ceramide metabolic process|
|sphingolipid biosynthetic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|positive regulation of autophagy|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|regulation of macroautophagy|
|organic hydroxy compound biosynthetic process|
|ammonium ion metabolic process|
|membrane lipid metabolic process|
|connective tissue development|
|phospholipid biosynthetic process|
|alcohol metabolic process|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|phospholipid metabolic process|
|positive regulation of catabolic process|
|organic hydroxy compound metabolic process|
|amide biosynthetic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular amide metabolic process|
|regulation of cellular catabolic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|regulation of catabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-4.08|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-3.75|
|[[:results:exp17|DABN 20μM R00 exp17]]|-3.71|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-3.69|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-3.59|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-3.52|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.31|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-3.22|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-3.18|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-3.04|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.85|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.82|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-2.64|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-2.38|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.3|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.29|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.15|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.11|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.06|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.01|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.99|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.94|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.94|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.93|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.92|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.89|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.88|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.81|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.76|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.74|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.72|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.82|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.94|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sptlc1|SPTLC1]]|0.634|
|[[:human genes:s:sptssa|SPTSSA]]|0.55|
|[[:human genes:c:chka|CHKA]]|0.467|
|[[:human genes:c:col4a3bp|COL4A3BP]]|0.465|
|[[:human genes:f:flvcr1|FLVCR1]]|0.46|
|[[:human genes:c:cept1|CEPT1]]|0.454|
|[[:human genes:p:pi4kb|PI4KB]]|0.435|
|[[:human genes:c:c10orf76|C10orf76]]|0.429|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.424|
|[[:human genes:w:wdr7|WDR7]]|0.421|
|[[:human genes:s:scap|SCAP]]|0.413|
|[[:human genes:m:mbtps1|MBTPS1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5491
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPTLC2 Expression in NALM6 Cells: 6.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>