======= SRC =======
== Gene Information ==
* **Official Symbol**: SRC
* **Official Name**: SRC proto-oncogene, non-receptor tyrosine kinase
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6714|6714]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P12931|P12931]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=SRC&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRC|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/190090|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta- catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). {ECO:0000250|UniProtKB:P05480, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.
|SH3 2|
|Pkinase Tyr|
|SH2|
|SH3 1|
|Pkinase|
|primary ovarian follicle growth|
|angiotensin-activated signaling pathway involved in heart process|
|positive regulation of ovarian follicle development|
|positive regulation of female gonad development|
|positive regulation of platelet-derived growth factor receptor-beta signaling pathway|
|cellular response to progesterone stimulus|
|postsynaptic specialization, intracellular component|
|growth factor receptor binding|
|positive regulation of platelet-derived growth factor receptor signaling pathway|
|regulation of caveolin-mediated endocytosis|
|regulation of ovarian follicle development|
|negative regulation of mitochondrial depolarization|
|connexin binding|
|negative regulation of membrane depolarization|
|positive regulation of lamellipodium morphogenesis|
|G protein-coupled receptor signaling pathway involved in heart process|
|positive regulation of non-membrane spanning protein tyrosine kinase activity|
|entry of bacterium into host cell|
|progesterone receptor signaling pathway|
|regulation of non-membrane spanning protein tyrosine kinase activity|
|osteoclast development|
|positive regulation of integrin activation|
|signal complex assembly|
|regulation of platelet-derived growth factor receptor-beta signaling pathway|
|angiotensin-activated signaling pathway|
|negative regulation of protein homooligomerization|
|BMP receptor binding|
|positive regulation of gonad development|
|regulation of lamellipodium morphogenesis|
|positive regulation of podosome assembly|
|regulation of postsynaptic neurotransmitter receptor activity|
|negative regulation of telomerase activity|
|regulation of female gonad development|
|regulation of integrin activation|
|regulation of podosome assembly|
|stress fiber assembly|
|contractile actin filament bundle assembly|
|negative regulation of protein oligomerization|
|negative regulation of anoikis|
|regulation of early endosome to late endosome transport|
|transcytosis|
|cellular response to fluid shear stress|
|negative regulation of focal adhesion assembly|
|regulation of gonad development|
|regulation of protein homooligomerization|
|negative regulation of telomere maintenance via telomerase|
|neurotrophin TRK receptor signaling pathway|
|cellular response to platelet-derived growth factor stimulus|
|regulation of mitochondrial depolarization|
|response to platelet-derived growth factor|
|negative regulation of adherens junction organization|
|cellular response to angiotensin|
|positive regulation of insulin receptor signaling pathway|
|insulin receptor binding|
|uterus development|
|negative regulation of cell junction assembly|
|regulation of platelet-derived growth factor receptor signaling pathway|
|positive regulation of protein processing|
|response to acidic pH|
|branching involved in mammary gland duct morphogenesis|
|regulation of anoikis|
|regulation of cytoplasmic transport|
|bone resorption|
|positive regulation of cellular response to insulin stimulus|
|positive regulation of protein maturation|
|bone cell development|
|response to angiotensin|
|negative regulation of telomere maintenance via telomere lengthening|
|positive regulation of protein autophosphorylation|
|positive regulation of lamellipodium organization|
|ephrin receptor binding|
|neurotrophin signaling pathway|
|podosome|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|mammary gland duct morphogenesis|
|ERBB2 signaling pathway|
|response to mineralocorticoid|
|activation of protein kinase B activity|
|peptidyl-tyrosine autophosphorylation|
|positive regulation of phosphatidylinositol 3-kinase activity|
|response to fluid shear stress|
|positive regulation of cyclin-dependent protein kinase activity|
|phosphoprotein binding|
|SH2 domain binding|
|positive regulation of lipid kinase activity|
|regulation of vascular permeability|
|negative regulation of telomere maintenance|
|positive regulation of smooth muscle cell migration|
|negative regulation of cell-matrix adhesion|
|positive regulation of glucose metabolic process|
|negative regulation of DNA biosynthetic process|
|regulation of bone resorption|
|response to pH|
|regulation of intracellular estrogen receptor signaling pathway|
|regulation of lamellipodium organization|
|mammary gland morphogenesis|
|estrogen receptor binding|
|regulation of protein oligomerization|
|response to electrical stimulus|
|ovulation cycle process|
|osteoclast differentiation|
|regulation of membrane depolarization|
|response to progesterone|
|protein destabilization|
|non-membrane spanning protein tyrosine kinase activity|
|bone remodeling|
|regulation of protein autophosphorylation|
|positive regulation of phospholipid metabolic process|
|regulation of bone remodeling|
|epidermal growth factor receptor signaling pathway|
|ovarian follicle development|
|regulation of telomerase activity|
|substrate adhesion-dependent cell spreading|
|SH3/SH2 adaptor activity|
|regulation of phosphatidylinositol 3-kinase activity|
|protein kinase C binding|
|regulation of telomere maintenance via telomerase|
|T cell costimulation|
|cellular response to fatty acid|
|lymphocyte costimulation|
|positive regulation of protein tyrosine kinase activity|
|mammary gland epithelium development|
|positive regulation of dephosphorylation|
|positive regulation of cellular carbohydrate metabolic process|
|myeloid cell development|
|scaffold protein binding|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|regulation of smooth muscle cell migration|
|regulation of telomere maintenance via telomere lengthening|
|extrinsic component of cytoplasmic side of plasma membrane|
|negative regulation of cell-substrate adhesion|
|regulation of lipid kinase activity|
|actin filament bundle assembly|
|regulation of insulin receptor signaling pathway|
|regulation of protein processing|
|actin filament bundle organization|
|vascular endothelial growth factor receptor signaling pathway|
|regulation of adherens junction organization|
|positive regulation of DNA biosynthetic process|
|ovulation cycle|
|intracellular steroid hormone receptor signaling pathway|
|regulation of protein maturation|
|cellular response to hydrogen peroxide|
|regulation of mitochondrial membrane potential|
|ERBB signaling pathway|
|positive regulation of small GTPase mediated signal transduction|
|regulation of cellular response to insulin stimulus|
|regulation of tissue remodeling|
|caveola|
|regulation of neurotransmitter receptor activity|
|positive regulation of organelle assembly|
|positive regulation of protein localization to nucleus|
|regulation of intracellular steroid hormone receptor signaling pathway|
|positive regulation of reproductive process|
|oogenesis|
|positive regulation of carbohydrate metabolic process|
|kinase activity|
|actin filament|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of telomere maintenance|
|adherens junction organization|
|response to fatty acid|
|regulation of phospholipid metabolic process|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|ephrin receptor signaling pathway|
|protein tyrosine kinase activity|
|female gonad development|
|regulation of protein tyrosine kinase activity|
|regulation of cell junction assembly|
|negative regulation of cysteine-type endopeptidase activity|
|cellular response to ketone|
|development of primary female sexual characteristics|
|kinase binding|
|integrin-mediated signaling pathway|
|ruffle membrane|
|negative regulation of intrinsic apoptotic signaling pathway|
|gland morphogenesis|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|heart process|
|tissue remodeling|
|negative regulation of extrinsic apoptotic signaling pathway|
|entry into host cell|
|regulation of cyclin-dependent protein kinase activity|
|transforming growth factor beta receptor signaling pathway|
|entry into host|
|female sex differentiation|
|myeloid leukocyte differentiation|
|regulation of DNA biosynthetic process|
|stimulatory C-type lectin receptor signaling pathway|
|regulation of glucose metabolic process|
|regulation of cell-matrix adhesion|
|actomyosin structure organization|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of protein localization to nucleus|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|steroid hormone mediated signaling pathway|
|regulation of phosphatidylinositol 3-kinase signaling|
|odontogenesis|
|negative regulation of DNA metabolic process|
|ion channel binding|
|late endosome|
|mammary gland development|
|female gamete generation|
|integrin binding|
|branching morphogenesis of an epithelial tube|
|negative regulation of protein complex assembly|
|cellular response to reactive oxygen species|
|negative regulation of chromosome organization|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|regulation of nervous system process|
|positive regulation of small molecule metabolic process|
|Fc receptor mediated stimulatory signaling pathway|
|platelet activation|
|regulation of cellular carbohydrate metabolic process|
|Fc-gamma receptor signaling pathway|
|positive regulation of cytokine secretion|
|positive regulation of epithelial cell migration|
|heme binding|
|positive regulation of lipid metabolic process|
|peptidyl-tyrosine phosphorylation|
|positive regulation of canonical Wnt signaling pathway|
|peptidyl-tyrosine modification|
|regulation of extrinsic apoptotic signaling pathway|
|cellular response to transforming growth factor beta stimulus|
|interaction with host|
|morphogenesis of a branching epithelium|
|regulation of reproductive process|
|regulation of intrinsic apoptotic signaling pathway|
|response to corticosteroid|
|macroautophagy|
|response to transforming growth factor beta|
|cellular response to insulin stimulus|
|intracellular receptor signaling pathway|
|positive regulation of protein kinase B signaling|
|morphogenesis of a branching structure|
|vascular process in circulatory system|
|hormone-mediated signaling pathway|
|regulation of signaling receptor activity|
|peptidyl-serine phosphorylation|
|positive regulation of Wnt signaling pathway|
|cellular response to lipopolysaccharide|
|cell-substrate adhesion|
|cellular response to hypoxia|
|cellular response to steroid hormone stimulus|
|protein C-terminus binding|
|positive regulation of peptidyl-tyrosine phosphorylation|
|tissue homeostasis|
|cellular response to molecule of bacterial origin|
|protein autophosphorylation|
|response to ketone|
|positive regulation of DNA metabolic process|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|peptidyl-serine modification|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|regulation of cell projection assembly|
|positive regulation of T cell activation|
|regulation of carbohydrate metabolic process|
|regulation of cytokine secretion|
|regulation of endocytosis|
|cellular response to acid chemical|
|gonad development|
|regulation of cell-substrate adhesion|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of dephosphorylation|
|response to mechanical stimulus|
|cellular response to toxic substance|
|cell junction organization|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|development of primary sexual characteristics|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|regulation of organelle assembly|
|myeloid cell differentiation|
|regulation of epithelial cell migration|
|negative regulation of apoptotic signaling pathway|
|response to insulin|
|innate immune response-activating signal transduction|
|protein kinase activity|
|cellular response to oxidative stress|
|actin filament organization|
|Fc receptor signaling pathway|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|positive regulation of protein complex assembly|
|lysosome|
|regulation of peptidyl-tyrosine phosphorylation|
|postsynaptic density|
|positive regulation of cell-cell adhesion|
|negative regulation of peptidase activity|
|germ cell development|
|activation of innate immune response|
|axon guidance|
|autophagy|
|positive regulation of MAP kinase activity|
|neuron projection guidance|
|process utilizing autophagic mechanism|
|sex differentiation|
|cellular response to peptide hormone stimulus|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|rhythmic process|
|negative regulation of transferase activity|
|response to virus|
|regulation of canonical Wnt signaling pathway|
|regulation of protein stability|
|positive regulation of peptide secretion|
|blood coagulation|
|regulation of ERK1 and ERK2 cascade|
|ubiquitin protein ligase binding|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|response to antibiotic|
|epithelial tube morphogenesis|
|cadherin binding|
|response to lipopolysaccharide|
|regulation of T cell activation|
|neuron projection|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|response to molecule of bacterial origin|
|cellular response to peptide|
|response to steroid hormone|
|activation of protein kinase activity|
|phagocytosis|
|leukocyte differentiation|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|response to hypoxia|
|response to acid chemical|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|enzyme binding|
|regulation of chromosome organization|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|cellular process involved in reproduction in multicellular organism|
|regulation of DNA metabolic process|
|positive regulation of proteolysis|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|regulation of Wnt signaling pathway|
|positive regulation of response to biotic stimulus|
|axonogenesis|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|regulation of binding|
|leukocyte migration|
|response to oxygen levels|
|positive regulation of cell projection organization|
|forebrain development|
|response to oxidative stress|
|blood circulation|
|response to peptide hormone|
|growth|
|regulation of lipid metabolic process|
|mitochondrial inner membrane|
|circulatory system process|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|axon development|
|gland development|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|reproductive structure development|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|reproductive system development|
|regulation of membrane potential|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|response to peptide|
|positive regulation of defense response|
|wound healing|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of peptide secretion|
|actin cytoskeleton organization|
|skeletal system development|
|regulation of body fluid levels|
|response to nutrient levels|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|response to growth factor|
|response to extracellular stimulus|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|positive regulation of locomotion|
|cell population proliferation|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|tissue morphogenesis|
|actin filament-based process|
|response to wounding|
|positive regulation of kinase activity|
|regulation of system process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|tube morphogenesis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of cell adhesion|
|response to bacterium|
|gamete generation|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|viral process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|head development|
|symbiotic process|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|multi-organism reproductive process|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|chemical homeostasis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.76|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 10510
* **Expression level (log2 read counts)**: 2.53
{{:chemogenomics:nalm6 dist.png?nolink |}}