======= SRCAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRCAP
  * **<color #00a2e8>Official Name</color>**: Snf2 related CREBBP activator protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10847|10847]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZRS2|Q6ZRS2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRCAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRCAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611421|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|SNF2 N|
|HSA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Swr1 complex|
|helicase activity|
|histone exchange|
|histone acetyltransferase activity|
|ATP-dependent chromatin remodeling|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|histone binding|
|protein acetylation|
|gene silencing|
|nucleosome organization|
|chromatin remodeling|
|protein acylation|
|ATPase activity|
|protein-DNA complex subunit organization|
|nuclear body|
|transcription coactivator activity|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|protein-containing complex|
|perinuclear region of cytoplasm|
|chromatin organization|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|Golgi apparatus|
|chromosome organization|
|DNA binding|
|ATP binding|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.33|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.09|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.87|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.77|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.77|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.74|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.08|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:h2afz|H2AFZ]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 115/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|9/28|
|bone|6/25|
|breast|3/33|
|central nervous system|15/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/15|
|kidney|3/21|
|liver|4/20|
|lung|10/75|
|lymphocyte|2/14|
|ovary|4/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|2/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 237
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRCAP Expression in NALM6 Cells: 7.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>