======= SRD5A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRD5A3
  * **<color #00a2e8>Official Name</color>**: steroid 5 alpha-reductase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79644|79644]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H8P0|Q9H8P0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRD5A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRD5A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611715|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). {ECO:0000269|PubMed:17986282, ECO:0000269|PubMed:20637498}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Steroid dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polyprenol reductase activity|
|dolichol biosynthetic process|
|polyprenol biosynthetic process|
|3-oxo-5-alpha-steroid 4-dehydrogenase activity|
|polyprenol catabolic process|
|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|
|cholestenone 5-alpha-reductase activity|
|dolichol metabolic process|
|dolichyl diphosphate biosynthetic process|
|dolichyl diphosphate metabolic process|
|polyprenol metabolic process|
|isoprenoid catabolic process|
|androgen biosynthetic process|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|androgen metabolic process|
|isoprenoid biosynthetic process|
|steroid hormone biosynthetic process|
|alcohol catabolic process|
|hormone biosynthetic process|
|organic hydroxy compound catabolic process|
|protein N-linked glycosylation|
|alcohol biosynthetic process|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|isoprenoid metabolic process|
|organic hydroxy compound biosynthetic process|
|cellular lipid catabolic process|
|hormone metabolic process|
|phospholipid biosynthetic process|
|protein glycosylation|
|macromolecule glycosylation|
|steroid metabolic process|
|glycosylation|
|lipid catabolic process|
|alcohol metabolic process|
|glycoprotein biosynthetic process|
|phospholipid metabolic process|
|glycoprotein metabolic process|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|regulation of hormone levels|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.99|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.82|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.7|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.71|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.73|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.73|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.85|
|[[:results:exp539|42°C R08 exp539]]|1.89|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.91|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.94|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.96|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.96|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.02|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.08|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.12|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.21|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.21|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.29|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dolk|DOLK]]|0.664|
|[[:human genes:d:dhrsx|DHRSX]]|0.664|
|[[:human genes:d:dpagt1|DPAGT1]]|0.607|
|[[:human genes:p:pgm3|PGM3]]|0.604|
|[[:human genes:a:alg6|ALG6]]|0.593|
|[[:human genes:a:alg1|ALG1]]|0.568|
|[[:human genes:p:ppcdc|PPCDC]]|0.566|
|[[:human genes:a:atxn10|ATXN10]]|0.561|
|[[:human genes:a:alg8|ALG8]]|0.56|
|[[:human genes:p:pmvk|PMVK]]|0.539|
|[[:human genes:l:lsm10|LSM10]]|0.526|
|[[:human genes:r:rft1|RFT1]]|0.524|
|[[:human genes:m:mbtps2|MBTPS2]]|0.523|
|[[:human genes:p:pmm2|PMM2]]|0.521|
|[[:human genes:v:vezt|VEZT]]|0.521|
|[[:human genes:r:rpia|RPIA]]|0.514|
|[[:human genes:t:trmt61a|TRMT61A]]|0.513|
|[[:human genes:r:romo1|ROMO1]]|0.503|
|[[:human genes:t:thg1l|THG1L]]|0.498|
|[[:human genes:s:srp14|SRP14]]|0.495|
|[[:human genes:a:atp2a2|ATP2A2]]|0.49|
|[[:human genes:d:dnlz|DNLZ]]|0.49|
|[[:human genes:p:ppcs|PPCS]]|0.489|
|[[:human genes:t:triap1|TRIAP1]]|0.488|
|[[:human genes:s:sec62|SEC62]]|0.486|
|[[:human genes:t:trmt6|TRMT6]]|0.486|
|[[:human genes:m:mbtps1|MBTPS1]]|0.481|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.481|
|[[:human genes:f:fh|FH]]|0.477|
|[[:human genes:u:uap1|UAP1]]|0.476|
|[[:human genes:k:kdsr|KDSR]]|0.471|
|[[:human genes:y:yars2|YARS2]]|0.471|
|[[:human genes:d:dohh|DOHH]]|0.47|
|[[:human genes:a:alg5|ALG5]]|0.469|
|[[:human genes:d:dap3|DAP3]]|0.469|
|[[:human genes:m:mrps6|MRPS6]]|0.468|
|[[:human genes:p:pars2|PARS2]]|0.468|
|[[:human genes:u:uso1|USO1]]|0.467|
|[[:human genes:g:gemin8|GEMIN8]]|0.462|
|[[:human genes:t:tpk1|TPK1]]|0.459|
|[[:human genes:p:ppa2|PPA2]]|0.453|
|[[:human genes:a:atic|ATIC]]|0.451|
|[[:human genes:d:dars2|DARS2]]|0.449|
|[[:human genes:m:mrpl23|MRPL23]]|0.445|
|[[:human genes:t:tbcb|TBCB]]|0.444|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.443|
|[[:human genes:m:mrps5|MRPS5]]|0.442|
|[[:human genes:r:rabggtb|RABGGTB]]|0.442|
|[[:human genes:m:mrps33|MRPS33]]|0.44|
|[[:human genes:c:c15orf41|C15orf41]]|0.438|
|[[:human genes:d:dpm3|DPM3]]|0.438|
|[[:human genes:s:sec63|SEC63]]|0.437|
|[[:human genes:s:slc25a26|SLC25A26]]|0.434|
|[[:human genes:a:atp5j|ATP5J]]|0.433|
|[[:human genes:t:trmt10a|TRMT10A]]|0.433|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.431|
|[[:human genes:c:c10orf2|C10orf2]]|0.43|
|[[:human genes:m:mrpl21|MRPL21]]|0.429|
|[[:human genes:a:alg3|ALG3]]|0.428|
|[[:human genes:g:gfpt1|GFPT1]]|0.427|
|[[:human genes:m:mrps14|MRPS14]]|0.426|
|[[:human genes:t:ten1|TEN1]]|0.426|
|[[:human genes:p:pggt1b|PGGT1B]]|0.423|
|[[:human genes:b:bcs1l|BCS1L]]|0.42|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.419|
|[[:human genes:m:mpdu1|MPDU1]]|0.419|
|[[:human genes:p:pgs1|PGS1]]|0.419|
|[[:human genes:c:crls1|CRLS1]]|0.417|
|[[:human genes:r:rpusd4|RPUSD4]]|0.416|
|[[:human genes:p:ptdss1|PTDSS1]]|0.416|
|[[:human genes:g:gatc|GATC]]|0.416|
|[[:human genes:s:ssb|SSB]]|0.415|
|[[:human genes:l:lars2|LARS2]]|0.414|
|[[:human genes:t:timm22|TIMM22]]|0.413|
|[[:human genes:m:mrps16|MRPS16]]|0.411|
|[[:human genes:a:alg13|ALG13]]|0.409|
|[[:human genes:g:gemin6|GEMIN6]]|0.409|
|[[:human genes:r:rpp21|RPP21]]|0.405|
|[[:human genes:v:vma21|VMA21]]|0.403|
|[[:human genes:m:mrpl15|MRPL15]]|0.402|
|[[:human genes:g:gemin7|GEMIN7]]|0.402|
|[[:human genes:m:mrps21|MRPS21]]|0.401|
|[[:human genes:c:cox17|COX17]]|0.401|
|[[:human genes:t:ttc4|TTC4]]|0.401|
|[[:human genes:u:uhrf1|UHRF1]]|0.401|
|[[:human genes:g:gfm1|GFM1]]|0.4|
|[[:human genes:d:ddx39a|DDX39A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1106
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRD5A3 Expression in NALM6 Cells: 2.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>