======= SREBF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SREBF2
  * **<color #00a2e8>Official Name</color>**: sterol regulatory element binding transcription factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6721|6721]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12772|Q12772]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SREBF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SREBF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600481|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|C-8 sterol isomerase activity|
|regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter|
|SREBP-SCAP-Insig complex|
|regulation of lipid transport by regulation of transcription from RNA polymerase II promoter|
|negative regulation of cholesterol efflux|
|cellular response to laminar fluid shear stress|
|positive regulation of cholesterol storage|
|negative regulation of sterol transport|
|negative regulation of cholesterol transport|
|response to laminar fluid shear stress|
|regulation of cholesterol storage|
|cellular response to fluid shear stress|
|cellular response to low-density lipoprotein particle stimulus|
|positive regulation of lipid storage|
|regulation of cholesterol efflux|
|negative regulation of lipid transport|
|response to lipoprotein particle|
|cellular response to lipoprotein particle stimulus|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|positive regulation of protein targeting to mitochondrion|
|response to fluid shear stress|
|negative regulation of lipid localization|
|regulation of autophagy of mitochondrion|
|regulation of pri-miRNA transcription by RNA polymerase II|
|regulation of cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|regulation of protein targeting to mitochondrion|
|regulation of cholesterol transport|
|regulation of lipid storage|
|regulation of sterol transport|
|E-box binding|
|ER to Golgi transport vesicle membrane|
|regulation of cholesterol metabolic process|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of establishment of protein localization to mitochondrion|
|regulation of alcohol biosynthetic process|
|cholesterol homeostasis|
|sterol homeostasis|
|positive regulation of lipid localization|
|regulation of protein targeting|
|regulation of steroid biosynthetic process|
|regulation of lipid transport|
|regulation of steroid metabolic process|
|positive regulation of mitochondrion organization|
|cholesterol metabolic process|
|secondary alcohol metabolic process|
|lipid homeostasis|
|sterol metabolic process|
|regulation of lipid localization|
|cellular response to starvation|
|positive regulation of intracellular protein transport|
|protein dimerization activity|
|regulation of mitochondrion organization|
|regulation of lipid biosynthetic process|
|protein C-terminus binding|
|response to starvation|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|cellular response to nutrient levels|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|steroid metabolic process|
|cellular response to extracellular stimulus|
|alcohol metabolic process|
|positive regulation of cellular protein localization|
|regulation of autophagy|
|cellular response to external stimulus|
|regulation of intracellular transport|
|regulation of lipid metabolic process|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|organic hydroxy compound metabolic process|
|positive regulation of establishment of protein localization|
|negative regulation of transport|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to extracellular stimulus|
|regulation of cellular protein localization|
|Golgi membrane|
|positive regulation of organelle organization|
|DNA-binding transcription factor activity|
|intracellular membrane-bounded organelle|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular catabolic process|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|positive regulation of transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|regulation of protein localization|
|response to nitrogen compound|
|chemical homeostasis|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-5.95|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-3.75|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.19|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.72|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.71|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.76|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.82|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.88|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.97|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.03|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:scap|SCAP]]|0.448|
|[[:human genes:c:c12orf49|C12orf49]]|0.414|
|[[:human genes:a:acat2|ACAT2]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8311
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SREBF2 Expression in NALM6 Cells: 8.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>