======= SRI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRI
  * **<color #00a2e8>Official Name</color>**: sorcin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6717|6717]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30626|P30626]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendritic spine neck|
|chromaffin granule membrane|
|intracellular sequestering of iron ion|
|negative regulation of cardiac muscle contraction|
|sequestering of iron ion|
|negative regulation of striated muscle contraction|
|regulation of cell communication by electrical coupling involved in cardiac conduction|
|regulation of relaxation of muscle|
|negative regulation of heart rate|
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|sequestering of metal ion|
|regulation of cell communication by electrical coupling|
|negative regulation of release of sequestered calcium ion into cytosol|
|regulation of high voltage-gated calcium channel activity|
|positive regulation of sequestering of calcium ion|
|cytoplasmic sequestering of transcription factor|
|negative regulation of calcium ion transport into cytosol|
|negative regulation of transcription regulatory region DNA binding|
|negative regulation of muscle contraction|
|negative regulation of heart contraction|
|cytoplasmic sequestering of protein|
|regulation of ryanodine-sensitive calcium-release channel activity|
|smooth endoplasmic reticulum|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|negative regulation of calcium-mediated signaling|
|sarcoplasmic reticulum membrane|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|negative regulation of blood circulation|
|regulation of voltage-gated calcium channel activity|
|negative regulation of calcium ion transmembrane transporter activity|
|calcium channel regulator activity|
|regulation of cardiac muscle cell contraction|
|negative regulation of calcium ion transmembrane transport|
|repressing transcription factor binding|
|positive regulation of release of sequestered calcium ion into cytosol|
|regulation of actin filament-based movement|
|negative regulation of cation channel activity|
|T-tubule|
|sarcoplasmic reticulum|
|axon terminus|
|regulation of transcription regulatory region DNA binding|
|positive regulation of calcium ion transport into cytosol|
|negative regulation of DNA binding|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|negative regulation of calcium ion transport|
|cellular iron ion homeostasis|
|regulation of cardiac conduction|
|positive regulation of calcium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|positive regulation of insulin secretion|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of transporter activity|
|iron ion homeostasis|
|negative regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transporter activity|
|regulation of striated muscle contraction|
|action potential|
|negative regulation of ion transmembrane transport|
|maintenance of location in cell|
|regulation of heart rate|
|regulation of calcium-mediated signaling|
|positive regulation of peptide hormone secretion|
|regulation of calcium ion transport into cytosol|
|protease binding|
|maintenance of protein location|
|cellular transition metal ion homeostasis|
|negative regulation of transmembrane transport|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|regulation of DNA binding|
|ion channel binding|
|positive regulation of hormone secretion|
|transition metal ion homeostasis|
|Z disc|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|positive regulation of ion transmembrane transport|
|negative regulation of DNA-binding transcription factor activity|
|regulation of muscle contraction|
|maintenance of location|
|negative regulation of binding|
|regulation of cation channel activity|
|regulation of insulin secretion|
|positive regulation of transmembrane transport|
|regulation of peptide hormone secretion|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|divalent metal ion transport|
|muscle organ development|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|regulation of binding|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|regulation of membrane potential|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|heart development|
|regulation of hormone levels|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|regulation of ion transport|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|circulatory system development|
|cellular homeostasis|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of protein localization|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|mitochondrion|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17318
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRI Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>