======= SRP68 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRP68
  * **<color #00a2e8>Official Name</color>**: signal recognition particle 68
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6730|6730]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHB9|Q9UHB9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRP68&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRP68|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604858|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum signal peptide binding|
|signal recognition particle binding|
|signal recognition particle|
|signal recognition particle, endoplasmic reticulum targeting|
|7S RNA binding|
|ribosome|
|ribosome binding|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|protein domain specific binding|
|establishment of protein localization to membrane|
|protein targeting|
|focal adhesion|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein localization to organelle|
|nucleolus|
|intracellular protein transport|
|endoplasmic reticulum|
|response to drug|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-2.07|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.97|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.94|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.9|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.9|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.9|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.87|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.82|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.78|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.76|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.75|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.71|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.7|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.84|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.87|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|3.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gtf3c2|GTF3C2]]|0.606|
|[[:human genes:r:rnmt|RNMT]]|0.574|
|[[:human genes:g:gmppb|GMPPB]]|0.524|
|[[:human genes:m:mapk14|MAPK14]]|0.519|
|[[:human genes:s:srp72|SRP72]]|0.512|
|[[:human genes:z:znf259|ZNF259]]|0.511|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.502|
|[[:human genes:e:eif4e|EIF4E]]|0.497|
|[[:human genes:h:hars|HARS]]|0.494|
|[[:human genes:m:med16|MED16]]|0.492|
|[[:human genes:n:nars|NARS]]|0.489|
|[[:human genes:a:aars|AARS]]|0.488|
|[[:human genes:t:tti2|TTI2]]|0.486|
|[[:human genes:d:dpagt1|DPAGT1]]|0.484|
|[[:human genes:p:polr3h|POLR3H]]|0.484|
|[[:human genes:r:rtcb|RTCB]]|0.48|
|[[:human genes:v:vrk1|VRK1]]|0.479|
|[[:human genes:o:oraov1|ORAOV1]]|0.478|
|[[:human genes:a:alg5|ALG5]]|0.476|
|[[:human genes:p:polr3b|POLR3B]]|0.475|
|[[:human genes:s:srprb|SRPRB]]|0.474|
|[[:human genes:h:haus8|HAUS8]]|0.474|
|[[:human genes:t:tti1|TTI1]]|0.469|
|[[:human genes:t:telo2|TELO2]]|0.467|
|[[:human genes:c:crcp|CRCP]]|0.465|
|[[:human genes:p:pmm2|PMM2]]|0.463|
|[[:human genes:n:nsmce1|NSMCE1]]|0.461|
|[[:human genes:a:alg1|ALG1]]|0.46|
|[[:human genes:t:thg1l|THG1L]]|0.46|
|[[:human genes:u:uxt|UXT]]|0.457|
|[[:human genes:s:srp19|SRP19]]|0.457|
|[[:human genes:g:gfpt1|GFPT1]]|0.455|
|[[:human genes:d:dad1|DAD1]]|0.449|
|[[:human genes:r:rptor|RPTOR]]|0.447|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.447|
|[[:human genes:d:dhps|DHPS]]|0.447|
|[[:human genes:c:ccdc101|CCDC101]]|0.446|
|[[:human genes:m:med4|MED4]]|0.443|
|[[:human genes:w:wars|WARS]]|0.443|
|[[:human genes:g:gemin5|GEMIN5]]|0.443|
|[[:human genes:t:tbca|TBCA]]|0.442|
|[[:human genes:n:nae1|NAE1]]|0.438|
|[[:human genes:c:csnk2b|CSNK2B]]|0.437|
|[[:human genes:p:pam16|PAM16]]|0.436|
|[[:human genes:d:dpf2|DPF2]]|0.434|
|[[:human genes:a:atxn10|ATXN10]]|0.432|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.432|
|[[:human genes:c:cct7|CCT7]]|0.429|
|[[:human genes:o:osgep|OSGEP]]|0.428|
|[[:human genes:d:dnajc3|DNAJC3]]|0.428|
|[[:human genes:t:tbp|TBP]]|0.427|
|[[:human genes:m:mars|MARS]]|0.427|
|[[:human genes:u:uap1|UAP1]]|0.426|
|[[:human genes:a:alg14|ALG14]]|0.425|
|[[:human genes:e:eny2|ENY2]]|0.424|
|[[:human genes:p:polr3c|POLR3C]]|0.423|
|[[:human genes:e:eef1e1|EEF1E1]]|0.422|
|[[:human genes:g:gnb1l|GNB1L]]|0.421|
|[[:human genes:r:rad1|RAD1]]|0.421|
|[[:human genes:t:triap1|TRIAP1]]|0.421|
|[[:human genes:e:exoc4|EXOC4]]|0.42|
|[[:human genes:g:gtf3a|GTF3A]]|0.419|
|[[:human genes:o:otud5|OTUD5]]|0.419|
|[[:human genes:a:alg2|ALG2]]|0.416|
|[[:human genes:m:mtor|MTOR]]|0.415|
|[[:human genes:h:hspd1|HSPD1]]|0.414|
|[[:human genes:a:alg13|ALG13]]|0.414|
|[[:human genes:s:spcs3|SPCS3]]|0.413|
|[[:human genes:a:alg6|ALG6]]|0.409|
|[[:human genes:d:dbr1|DBR1]]|0.409|
|[[:human genes:t:tmem41b|TMEM41B]]|0.406|
|[[:human genes:e:eprs|EPRS]]|0.405|
|[[:human genes:t:tsen2|TSEN2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 124/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|3/28|
|bone|3/26|
|breast|7/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|2/21|
|liver|3/20|
|lung|14/75|
|lymphocyte|2/16|
|ovary|5/26|
|pancreas|7/24|
|peripheral nervous system|2/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2706
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRP68 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>