======= SRP9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRP9
  * **<color #00a2e8>Official Name</color>**: signal recognition particle 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6726|6726]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49458|P49458]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRP9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRP9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600707|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRP9-21|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signal recognition particle binding|
|negative regulation of translational elongation|
|signal recognition particle receptor complex|
|signal recognition particle, endoplasmic reticulum targeting|
|7S RNA binding|
|regulation of translational elongation|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|negative regulation of translation|
|protein localization to endoplasmic reticulum|
|negative regulation of cellular amide metabolic process|
|protein targeting to membrane|
|establishment of protein localization to membrane|
|regulation of translation|
|protein targeting|
|regulation of cellular amide metabolic process|
|establishment of protein localization to organelle|
|protein localization to membrane|
|posttranscriptional regulation of gene expression|
|protein localization to organelle|
|intracellular protein transport|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of gene expression|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.72|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.11|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:srp14|SRP14]]|0.467|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.445|
|[[:human genes:c:c16orf59|C16orf59]]|0.437|
|[[:human genes:c:c14orf80|C14orf80]]|0.436|
|[[:human genes:c:cep120|CEP120]]|0.43|
|[[:human genes:t:tubd1|TUBD1]]|0.417|
|[[:human genes:c:c2cd3|C2CD3]]|0.404|
|[[:human genes:o:odf2|ODF2]]|0.401|
|[[:human genes:c:cep44|CEP44]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 69/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|3/26|
|breast|2/33|
|central nervous system|8/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|1/21|
|liver|2/20|
|lung|7/75|
|lymphocyte|3/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2069
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRP9 Expression in NALM6 Cells: 7.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>