======= SSB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SSB
  * **<color #00a2e8>Official Name</color>**: small RNA binding exonuclease protection factor La
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6741|6741]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05455|P05455]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SSB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SSB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|RRM 3|
|La|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear histone mRNA catabolic process|
|protein localization to cytoplasmic stress granule|
|tRNA 3-end processing|
|IRES-dependent viral translational initiation|
|sequence-specific mRNA binding|
|tRNA 5-leader removal|
|viral translation|
|histone mRNA catabolic process|
|tRNA 5-end processing|
|ncRNA 5-end processing|
|RNA 5-end processing|
|poly(U) RNA binding|
|histone mRNA metabolic process|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|ncRNA 3-end processing|
|tRNA binding|
|tRNA modification|
|nuclear chromosome, telomeric region|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|tRNA processing|
|RNA 3-end processing|
|protein export from nucleus|
|ribonucleoprotein complex|
|nuclear export|
|mRNA binding|
|RNA modification|
|tRNA metabolic process|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA localization|
|nucleobase-containing compound transport|
|RNA catabolic process|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.65|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.28|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-2.13|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-2.07|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.97|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.85|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.84|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.84|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.77|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.73|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.73|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.72|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.71|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.7|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.76|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.79|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.81|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.85|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.89|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.96|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.97|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.01|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.2|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.573|
|[[:human genes:r:rpp21|RPP21]]|0.554|
|[[:human genes:l:lsm10|LSM10]]|0.535|
|[[:human genes:d:dolk|DOLK]]|0.531|
|[[:human genes:u:urm1|URM1]]|0.53|
|[[:human genes:d:dhrsx|DHRSX]]|0.527|
|[[:human genes:k:kdsr|KDSR]]|0.52|
|[[:human genes:a:adsl|ADSL]]|0.517|
|[[:human genes:s:sec62|SEC62]]|0.516|
|[[:human genes:a:alg6|ALG6]]|0.513|
|[[:human genes:g:gmppb|GMPPB]]|0.511|
|[[:human genes:a:alg13|ALG13]]|0.506|
|[[:human genes:r:rft1|RFT1]]|0.505|
|[[:human genes:d:dohh|DOHH]]|0.505|
|[[:human genes:t:triap1|TRIAP1]]|0.503|
|[[:human genes:r:rptor|RPTOR]]|0.501|
|[[:human genes:d:dpagt1|DPAGT1]]|0.495|
|[[:human genes:a:atic|ATIC]]|0.494|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.494|
|[[:human genes:e:exoc4|EXOC4]]|0.492|
|[[:human genes:u:uap1|UAP1]]|0.491|
|[[:human genes:t:trmt61a|TRMT61A]]|0.49|
|[[:human genes:p:ppa2|PPA2]]|0.488|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.488|
|[[:human genes:a:alg1|ALG1]]|0.483|
|[[:human genes:p:pmm2|PMM2]]|0.482|
|[[:human genes:r:rtcb|RTCB]]|0.481|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.479|
|[[:human genes:e:elac2|ELAC2]]|0.478|
|[[:human genes:e:elp3|ELP3]]|0.477|
|[[:human genes:m:mocs3|MOCS3]]|0.477|
|[[:human genes:u:ube2g2|UBE2G2]]|0.475|
|[[:human genes:a:atp5b|ATP5B]]|0.474|
|[[:human genes:e:elp2|ELP2]]|0.474|
|[[:human genes:a:atp5o|ATP5O]]|0.473|
|[[:human genes:t:trmt10a|TRMT10A]]|0.473|
|[[:human genes:g:gfpt1|GFPT1]]|0.473|
|[[:human genes:v:vezt|VEZT]]|0.471|
|[[:human genes:a:atp5a1|ATP5A1]]|0.47|
|[[:human genes:a:atp5j|ATP5J]]|0.47|
|[[:human genes:e:eny2|ENY2]]|0.469|
|[[:human genes:t:trnt1|TRNT1]]|0.468|
|[[:human genes:y:yars2|YARS2]]|0.466|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.465|
|[[:human genes:d:dars2|DARS2]]|0.464|
|[[:human genes:g:gemin6|GEMIN6]]|0.464|
|[[:human genes:f:fh|FH]]|0.463|
|[[:human genes:p:pgm3|PGM3]]|0.463|
|[[:human genes:t:tsen54|TSEN54]]|0.461|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.46|
|[[:human genes:d:dr1|DR1]]|0.459|
|[[:human genes:m:mbtps2|MBTPS2]]|0.457|
|[[:human genes:p:ppcs|PPCS]]|0.457|
|[[:human genes:b:bap1|BAP1]]|0.456|
|[[:human genes:b:bcs1l|BCS1L]]|0.456|
|[[:human genes:a:atxn10|ATXN10]]|0.452|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.45|
|[[:human genes:e:elp6|ELP6]]|0.45|
|[[:human genes:s:slc25a26|SLC25A26]]|0.449|
|[[:human genes:s:srp14|SRP14]]|0.448|
|[[:human genes:u:uhrf1|UHRF1]]|0.448|
|[[:human genes:c:cbfb|CBFB]]|0.447|
|[[:human genes:r:romo1|ROMO1]]|0.447|
|[[:human genes:n:ndufb1|NDUFB1]]|0.445|
|[[:human genes:m:mrpl20|MRPL20]]|0.444|
|[[:human genes:d:dap3|DAP3]]|0.441|
|[[:human genes:t:ten1|TEN1]]|0.44|
|[[:human genes:a:alg8|ALG8]]|0.439|
|[[:human genes:r:rpia|RPIA]]|0.439|
|[[:human genes:w:wdr24|WDR24]]|0.439|
|[[:human genes:r:rnmt|RNMT]]|0.439|
|[[:human genes:h:hccs|HCCS]]|0.439|
|[[:human genes:e:eef1e1|EEF1E1]]|0.438|
|[[:human genes:n:nsd1|NSD1]]|0.438|
|[[:human genes:m:mrps16|MRPS16]]|0.437|
|[[:human genes:m:mrps5|MRPS5]]|0.436|
|[[:human genes:t:ttc4|TTC4]]|0.433|
|[[:human genes:t:trmt5|TRMT5]]|0.433|
|[[:human genes:r:rpe|RPE]]|0.432|
|[[:human genes:u:uba5|UBA5]]|0.43|
|[[:human genes:p:ppp6c|PPP6C]]|0.43|
|[[:human genes:m:mrps14|MRPS14]]|0.429|
|[[:human genes:l:lsm11|LSM11]]|0.429|
|[[:human genes:t:tars2|TARS2]]|0.429|
|[[:human genes:t:tpk1|TPK1]]|0.427|
|[[:human genes:r:rbfa|RBFA]]|0.427|
|[[:human genes:w:wdr59|WDR59]]|0.426|
|[[:human genes:m:msto1|MSTO1]]|0.424|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.424|
|[[:human genes:m:maml1|MAML1]]|0.424|
|[[:human genes:t:txnl4b|TXNL4B]]|0.423|
|[[:human genes:t:tmem242|TMEM242]]|0.421|
|[[:human genes:p:pars2|PARS2]]|0.421|
|[[:human genes:b:bak1|BAK1]]|0.421|
|[[:human genes:c:cycs|CYCS]]|0.42|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.418|
|[[:human genes:p:pdap1|PDAP1]]|0.416|
|[[:human genes:t:tufm|TUFM]]|0.416|
|[[:human genes:s:srd5a3|SRD5A3]]|0.415|
|[[:human genes:s:sars2|SARS2]]|0.415|
|[[:human genes:c:casp9|CASP9]]|0.415|
|[[:human genes:s:selrc1|SELRC1]]|0.415|
|[[:human genes:v:vhl|VHL]]|0.415|
|[[:human genes:c:ctu1|CTU1]]|0.414|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.414|
|[[:human genes:g:gemin8|GEMIN8]]|0.413|
|[[:human genes:m:mrpl21|MRPL21]]|0.413|
|[[:human genes:m:mrps18a|MRPS18A]]|0.412|
|[[:human genes:m:mrp63|MRP63]]|0.412|
|[[:human genes:m:mrps6|MRPS6]]|0.412|
|[[:human genes:i:id3|ID3]]|0.411|
|[[:human genes:s:sec61g|SEC61G]]|0.41|
|[[:human genes:p:ppcdc|PPCDC]]|0.41|
|[[:human genes:a:atp5h|ATP5H]]|0.409|
|[[:human genes:t:tmem41b|TMEM41B]]|0.408|
|[[:human genes:g:gemin7|GEMIN7]]|0.407|
|[[:human genes:a:alg5|ALG5]]|0.407|
|[[:human genes:c:c15orf41|C15orf41]]|0.406|
|[[:human genes:t:tprkb|TPRKB]]|0.405|
|[[:human genes:m:mrps2|MRPS2]]|0.404|
|[[:human genes:n:nars2|NARS2]]|0.403|
|[[:human genes:h:hspd1|HSPD1]]|0.403|
|[[:human genes:c:cbx3|CBX3]]|0.401|
|[[:human genes:p:polg|POLG]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12754
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SSB Expression in NALM6 Cells: 7.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>