======= SSBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SSBP1
  * **<color #00a2e8>Official Name</color>**: single stranded DNA binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6742|6742]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q04837|Q04837]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SSBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SSBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600439|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SSB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of helicase activity|
|mitochondrial DNA replication|
|regulation of helicase activity|
|mitochondrion morphogenesis|
|mitochondrial nucleoid|
|positive regulation of ATPase activity|
|regulation of ATPase activity|
|single-stranded DNA binding|
|DNA-dependent DNA replication|
|DNA replication|
|mitochondrial matrix|
|chromatin binding|
|mitochondrion organization|
|cell part morphogenesis|
|positive regulation of hydrolase activity|
|cellular component morphogenesis|
|mitochondrion|
|regulation of hydrolase activity|
|RNA binding|
|positive regulation of catalytic activity|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.87|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.72|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.77|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.77|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.78|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.79|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.79|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.81|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.81|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.82|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.88|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.88|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.9|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.9|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.93|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.98|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.98|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.03|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.03|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.04|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.17|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.18|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.3|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.42|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.44|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.48|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.48|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lars2|LARS2]]|0.559|
|[[:human genes:g:grsf1|GRSF1]]|0.559|
|[[:human genes:p:polg2|POLG2]]|0.556|
|[[:human genes:f:ftsj2|FTSJ2]]|0.548|
|[[:human genes:n:nars2|NARS2]]|0.545|
|[[:human genes:c:chchd1|CHCHD1]]|0.537|
|[[:human genes:n:ndufb11|NDUFB11]]|0.532|
|[[:human genes:n:ndufa1|NDUFA1]]|0.531|
|[[:human genes:a:acad9|ACAD9]]|0.528|
|[[:human genes:f:fastkd2|FASTKD2]]|0.524|
|[[:human genes:n:nubpl|NUBPL]]|0.518|
|[[:human genes:d:dap3|DAP3]]|0.517|
|[[:human genes:m:mrpl45|MRPL45]]|0.512|
|[[:human genes:n:ndufs2|NDUFS2]]|0.506|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.503|
|[[:human genes:m:mtg2|MTG2]]|0.503|
|[[:human genes:n:ndufa11|NDUFA11]]|0.499|
|[[:human genes:n:ndufb10|NDUFB10]]|0.498|
|[[:human genes:c:cars2|CARS2]]|0.497|
|[[:human genes:p:pet117|PET117]]|0.497|
|[[:human genes:s:sfxn4|SFXN4]]|0.493|
|[[:human genes:m:mrpl21|MRPL21]]|0.493|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.492|
|[[:human genes:m:malsu1|MALSU1]]|0.492|
|[[:human genes:m:mtif2|MTIF2]]|0.492|
|[[:human genes:n:ndufc2|NDUFC2]]|0.489|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.486|
|[[:human genes:c:c12orf65|C12orf65]]|0.486|
|[[:human genes:r:rpusd3|RPUSD3]]|0.485|
|[[:human genes:q:qrsl1|QRSL1]]|0.484|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.483|
|[[:human genes:n:ndufb9|NDUFB9]]|0.482|
|[[:human genes:n:ndufb6|NDUFB6]]|0.482|
|[[:human genes:g:gfm2|GFM2]]|0.479|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.478|
|[[:human genes:m:mtg1|MTG1]]|0.477|
|[[:human genes:m:mto1|MTO1]]|0.477|
|[[:human genes:n:ndufb7|NDUFB7]]|0.475|
|[[:human genes:t:tfb1m|TFB1M]]|0.474|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.473|
|[[:human genes:m:mrpl22|MRPL22]]|0.473|
|[[:human genes:p:pars2|PARS2]]|0.472|
|[[:human genes:p:pet112|PET112]]|0.469|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.464|
|[[:human genes:m:mrps21|MRPS21]]|0.464|
|[[:human genes:g:gfm1|GFM1]]|0.463|
|[[:human genes:m:mrpl3|MRPL3]]|0.461|
|[[:human genes:n:ndufa3|NDUFA3]]|0.46|
|[[:human genes:n:ndufs1|NDUFS1]]|0.46|
|[[:human genes:m:mrps7|MRPS7]]|0.459|
|[[:human genes:w:wbscr16|WBSCR16]]|0.459|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.459|
|[[:human genes:p:pde12|PDE12]]|0.457|
|[[:human genes:r:rpusd4|RPUSD4]]|0.457|
|[[:human genes:m:mrp63|MRP63]]|0.456|
|[[:human genes:d:ddx28|DDX28]]|0.456|
|[[:human genes:m:mcat|MCAT]]|0.454|
|[[:human genes:m:mrpl4|MRPL4]]|0.454|
|[[:human genes:p:ptcd3|PTCD3]]|0.454|
|[[:human genes:t:tars2|TARS2]]|0.452|
|[[:human genes:a:aars2|AARS2]]|0.452|
|[[:human genes:a:atp5sl|ATP5SL]]|0.451|
|[[:human genes:f:fastkd5|FASTKD5]]|0.449|
|[[:human genes:t:tomm6|TOMM6]]|0.448|
|[[:human genes:t:tmem261|TMEM261]]|0.448|
|[[:human genes:n:ndufc1|NDUFC1]]|0.447|
|[[:human genes:m:mrpl20|MRPL20]]|0.446|
|[[:human genes:p:prepl|PREPL]]|0.446|
|[[:human genes:m:mettl17|METTL17]]|0.445|
|[[:human genes:m:mrpl49|MRPL49]]|0.444|
|[[:human genes:n:ndufa2|NDUFA2]]|0.444|
|[[:human genes:m:mrps16|MRPS16]]|0.443|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.44|
|[[:human genes:p:polrmt|POLRMT]]|0.44|
|[[:human genes:m:mrpl1|MRPL1]]|0.439|
|[[:human genes:c:c1qbp|C1QBP]]|0.439|
|[[:human genes:p:polg|POLG]]|0.439|
|[[:human genes:c:coa3|COA3]]|0.437|
|[[:human genes:m:mrps18b|MRPS18B]]|0.437|
|[[:human genes:c:cox11|COX11]]|0.434|
|[[:human genes:m:mipep|MIPEP]]|0.434|
|[[:human genes:m:mrpl47|MRPL47]]|0.433|
|[[:human genes:m:mrps9|MRPS9]]|0.432|
|[[:human genes:m:mrps6|MRPS6]]|0.432|
|[[:human genes:m:mrps5|MRPS5]]|0.431|
|[[:human genes:s:selrc1|SELRC1]]|0.43|
|[[:human genes:m:mterfd2|MTERFD2]]|0.426|
|[[:human genes:m:mrpl23|MRPL23]]|0.425|
|[[:human genes:n:nsun4|NSUN4]]|0.424|
|[[:human genes:m:mrpl44|MRPL44]]|0.423|
|[[:human genes:m:mrpl12|MRPL12]]|0.423|
|[[:human genes:m:mrps25|MRPS25]]|0.422|
|[[:human genes:r:rars2|RARS2]]|0.421|
|[[:human genes:m:mrpl53|MRPL53]]|0.421|
|[[:human genes:n:ndufb3|NDUFB3]]|0.419|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.418|
|[[:human genes:y:yars2|YARS2]]|0.417|
|[[:human genes:m:mterfd1|MTERFD1]]|0.417|
|[[:human genes:n:ndufs5|NDUFS5]]|0.416|
|[[:human genes:n:ndufa8|NDUFA8]]|0.416|
|[[:human genes:e:ecsit|ECSIT]]|0.412|
|[[:human genes:c:clpp|CLPP]]|0.411|
|[[:human genes:e:ears2|EARS2]]|0.41|
|[[:human genes:a:aifm1|AIFM1]]|0.409|
|[[:human genes:d:dars2|DARS2]]|0.409|
|[[:human genes:c:cox16|COX16]]|0.407|
|[[:human genes:e:eral1|ERAL1]]|0.405|
|[[:human genes:n:ndufv1|NDUFV1]]|0.404|
|[[:human genes:c:coq2|COQ2]]|0.404|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.403|
|[[:human genes:m:mrps22|MRPS22]]|0.403|
|[[:human genes:m:mrps26|MRPS26]]|0.402|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.402|
|[[:human genes:m:mrps23|MRPS23]]|0.402|
|[[:human genes:m:mrpl39|MRPL39]]|0.402|
|[[:human genes:m:mrpl43|MRPL43]]|0.402|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.401|
|[[:human genes:r:rbfa|RBFA]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|1/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1719
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SSBP1 Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>