======= SSR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SSR2
  * **<color #00a2e8>Official Name</color>**: signal sequence receptor subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6746|6746]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43308|P43308]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SSR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SSR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600867|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRAP beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cotranslational protein targeting to membrane|
|protein targeting to membrane|
|establishment of protein localization to membrane|
|protein targeting|
|in utero embryonic development|
|protein localization to membrane|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|endoplasmic reticulum membrane|
|embryo development|
|intracellular protein transport|
|endoplasmic reticulum|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-3.02|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.88|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.8|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.79|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.78|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.77|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.72|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.8|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.84|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.91|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.96|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.05|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.05|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|2.1|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.16|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:ssr3|SSR3]]|0.486|
|[[:human genes:s:ssr1|SSR1]]|0.476|
|[[:human genes:i:igll1|IGLL1]]|0.422|
|[[:human genes:p:pik3cd|PIK3CD]]|0.417|
|[[:human genes:s:syk|SYK]]|0.415|
|[[:human genes:r:rhoh|RHOH]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17455
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SSR2 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>