======= ST14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ST14
  * **<color #00a2e8>Official Name</color>**: suppression of tumorigenicity 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6768|6768]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5Y6|Q9Y5Y6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ST14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ST14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606797|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. {ECO:0000269|PubMed:18843291}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CUB|
|Trypsin|
|Ldl recept a|
|SEA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epithelial cell morphogenesis involved in placental branching|
|epithelial cell differentiation involved in embryonic placenta development|
|branching involved in labyrinthine layer morphogenesis|
|labyrinthine layer morphogenesis|
|embryonic placenta morphogenesis|
|cell differentiation involved in embryonic placenta development|
|extrinsic component of plasma membrane|
|epithelial cell morphogenesis|
|labyrinthine layer development|
|serine-type peptidase activity|
|embryonic placenta development|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|neural tube formation|
|cornification|
|embryonic epithelial tube formation|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|placenta development|
|morphogenesis of a branching epithelium|
|neural tube development|
|serine-type endopeptidase activity|
|morphogenesis of a branching structure|
|epithelial cell development|
|basolateral plasma membrane|
|keratinization|
|keratinocyte differentiation|
|epithelial tube morphogenesis|
|epidermal cell differentiation|
|in utero embryonic development|
|skin development|
|epidermis development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|cell morphogenesis|
|cellular component morphogenesis|
|tube development|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|programmed cell death|
|cell death|
|epithelium development|
|proteolysis|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|extracellular space|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.93|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.72|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9784
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ST14 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>