======= STAMBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STAMBP
  * **<color #00a2e8>Official Name</color>**: STAM binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10617|10617]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95630|O95630]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STAMBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STAMBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606247|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. {ECO:0000250, ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mov34|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Lys63-specific deubiquitinase activity|
|negative regulation of phosphatidylinositol 3-kinase signaling|
|protein K63-linked deubiquitination|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|negative regulation of Ras protein signal transduction|
|cleavage furrow|
|negative regulation of small GTPase mediated signal transduction|
|metallopeptidase activity|
|mitotic cytokinesis|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|thiol-dependent ubiquitin-specific protease activity|
|regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of neuron apoptotic process|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|regulation of Ras protein signal transduction|
|protein domain specific binding|
|early endosome|
|endosome|
|protein deubiquitination|
|protein modification by small protein removal|
|regulation of neuron death|
|regulation of small GTPase mediated signal transduction|
|cell division|
|negative regulation of intracellular signal transduction|
|mitotic cell cycle process|
|mitotic cell cycle|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|cell cycle process|
|negative regulation of signal transduction|
|proteolysis|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of cell death|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.87|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.85|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.75|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.74|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.77|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 71/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|2/26|
|breast|2/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|8/21|
|liver|0/20|
|lung|8/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|9/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8791
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STAMBP Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>