======= STARD13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STARD13
  * **<color #00a2e8>Official Name</color>**: StAR related lipid transfer domain containing 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90627|90627]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3M8|Q9Y3M8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STARD13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STARD13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609866|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|START|
|RhoGAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endothelial tube lumen extension|
|morphogenesis of an endothelium|
|endothelial tube morphogenesis|
|negative regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of sprouting angiogenesis|
|negative regulation of blood vessel endothelial cell migration|
|regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of endothelial cell migration|
|endothelial cell migration|
|negative regulation of epithelial cell migration|
|regulation of sprouting angiogenesis|
|lipid droplet|
|epithelial cell migration|
|epithelium migration|
|regulation of blood vessel endothelial cell migration|
|tissue migration|
|endothelium development|
|mitochondrial membrane|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|lipid binding|
|regulation of endothelial cell migration|
|ameboidal-type cell migration|
|regulation of epithelial cell migration|
|negative regulation of cell migration|
|negative regulation of cell motility|
|GTPase activator activity|
|regulation of angiogenesis|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of small GTPase mediated signal transduction|
|positive regulation of GTPase activity|
|morphogenesis of an epithelium|
|regulation of GTPase activity|
|tissue morphogenesis|
|tube morphogenesis|
|positive regulation of hydrolase activity|
|tube development|
|regulation of cell migration|
|regulation of cell motility|
|negative regulation of developmental process|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|epithelium development|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|tissue development|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13371
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STARD13 Expression in NALM6 Cells: 2.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>