======= STARD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STARD3
  * **<color #00a2e8>Official Name</color>**: StAR related lipid transfer domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10948|10948]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14849|Q14849]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STARD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STARD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607048|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544). {ECO:0000269|PubMed:11053434, ECO:0000269|PubMed:12070139, ECO:0000269|PubMed:15930133, ECO:0000269|PubMed:19965586, ECO:0000269|PubMed:21322544, ECO:0000269|PubMed:22514632, ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:28377464}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MENTAL|
|START|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle tethering to endoplasmic reticulum|
|progesterone biosynthetic process|
|endoplasmic reticulum-endosome membrane contact site|
|organelle membrane contact site|
|vesicle tethering|
|progesterone metabolic process|
|C21-steroid hormone biosynthetic process|
|ketone biosynthetic process|
|C21-steroid hormone metabolic process|
|steroid hormone biosynthetic process|
|cholesterol binding|
|cholesterol transport|
|hormone biosynthetic process|
|sterol transport|
|cellular ketone metabolic process|
|vesicle targeting|
|cholesterol metabolic process|
|late endosome membrane|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|organic hydroxy compound transport|
|establishment of vesicle localization|
|vesicle localization|
|hormone metabolic process|
|mitochondrial transport|
|steroid metabolic process|
|lipid transport|
|lysosomal membrane|
|alcohol metabolic process|
|lipid localization|
|establishment of organelle localization|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|organelle localization|
|small molecule biosynthetic process|
|protein homodimerization activity|
|endoplasmic reticulum membrane|
|lipid metabolic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|small molecule metabolic process|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.66|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.21|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.11|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.1|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.81|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.78|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.77|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.71|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.77|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.82|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.83|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.89|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.89|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.98|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|2.44|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4743
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STARD3 Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>