======= STARD3NL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STARD3NL
  * **<color #00a2e8>Official Name</color>**: STARD3 N-terminal like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83930|83930]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95772|O95772]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STARD3NL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STARD3NL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611759|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a late-endosomal protein that contains a conserved MENTAL (MLN64 N-terminal) domain. The encoded protein binds cholesterol molecules and may play a role in endosomal cholesterol transport through interactions with metastatic lymph node protein 64 (MLN64). [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269|PubMed:24105263}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MENTAL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle tethering to endoplasmic reticulum|
|endoplasmic reticulum-endosome membrane contact site|
|organelle membrane contact site|
|vesicle tethering|
|C21-steroid hormone biosynthetic process|
|C21-steroid hormone metabolic process|
|steroid hormone biosynthetic process|
|cholesterol binding|
|hormone biosynthetic process|
|vesicle targeting|
|late endosome membrane|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|establishment of vesicle localization|
|vesicle localization|
|hormone metabolic process|
|steroid metabolic process|
|lysosomal membrane|
|establishment of organelle localization|
|regulation of hormone levels|
|lipid biosynthetic process|
|organelle localization|
|intracellular membrane-bounded organelle|
|protein homodimerization activity|
|endoplasmic reticulum membrane|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|establishment of localization in cell|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.72|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.75|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.95|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.95|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.97|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.04|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16973
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STARD3NL Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>