======= STARD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STARD4
  * **<color #00a2e8>Official Name</color>**: StAR related lipid transfer domain containing 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=134429|134429]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DR4|Q96DR4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STARD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STARD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607049|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|START|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cholesterol transport involved in cholesterol storage|
|lipid transport involved in lipid storage|
|cholesterol storage|
|positive regulation of bile acid metabolic process|
|positive regulation of bile acid biosynthetic process|
|cholesterol import|
|sterol import|
|positive regulation of cholesterol esterification|
|regulation of bile acid biosynthetic process|
|regulation of cholesterol esterification|
|regulation of bile acid metabolic process|
|intracellular cholesterol transport|
|intracellular sterol transport|
|positive regulation of steroid biosynthetic process|
|cholesterol transfer activity|
|positive regulation of steroid metabolic process|
|lipid storage|
|intracellular lipid transport|
|cholesterol binding|
|cholesterol transport|
|sterol transport|
|positive regulation of lipid biosynthetic process|
|regulation of steroid biosynthetic process|
|regulation of steroid metabolic process|
|positive regulation of small molecule metabolic process|
|organic hydroxy compound transport|
|positive regulation of lipid metabolic process|
|maintenance of location|
|regulation of cellular ketone metabolic process|
|regulation of lipid biosynthetic process|
|cytoplasmic vesicle|
|lipid transport|
|lipid localization|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|intracellular transport|
|establishment of localization in cell|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.85|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.83|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.88|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17262
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STARD4 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>