======= STAT4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STAT4
  * **<color #00a2e8>Official Name</color>**: signal transducer and activator of transcription 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6775|6775]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14765|Q14765]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STAT4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STAT4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600558|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|STAT alpha|
|STAT int|
|SH2|
|STAT bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-21-mediated signaling pathway|
|response to interleukin-21|
|cellular response to interleukin-21|
|interleukin-23-mediated signaling pathway|
|interleukin-35-mediated signaling pathway|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|response to peptide hormone|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|response to peptide|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|response to hormone|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|identical protein binding|
|response to nitrogen compound|
|response to cytokine|
|positive regulation of transcription by RNA polymerase II|
|defense response|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.93|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8861
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STAT4 Expression in NALM6 Cells: 1.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>