======= STC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STC1
  * **<color #00a2e8>Official Name</color>**: stanniocalcin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6781|6781]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52823|P52823]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601185|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Stanniocalcin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of renal phosphate excretion|
|growth plate cartilage axis specification|
|negative regulation of renal phosphate excretion|
|chondrocyte proliferation|
|endothelial cell morphogenesis|
|growth plate cartilage morphogenesis|
|positive regulation of calcium ion import|
|regulation of excretion|
|decidualization|
|cartilage morphogenesis|
|response to vitamin D|
|growth plate cartilage development|
|epithelial cell morphogenesis|
|maternal placenta development|
|regulation of renal system process|
|embryo implantation|
|regulation of cardiac muscle cell contraction|
|regulation of calcium ion import|
|endochondral bone growth|
|regulation of actin filament-based movement|
|cartilage development involved in endochondral bone morphogenesis|
|bone growth|
|negative regulation of endothelial cell migration|
|endothelial cell development|
|cellular response to cAMP|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|negative regulation of calcium ion transport|
|maternal process involved in female pregnancy|
|negative regulation of epithelial cell migration|
|endochondral bone morphogenesis|
|regulation of cardiac muscle contraction|
|endothelial cell differentiation|
|axis specification|
|response to vitamin|
|regulation of striated muscle contraction|
|endothelium development|
|regulation of anion transport|
|organ growth|
|hormone activity|
|response to cAMP|
|bone morphogenesis|
|positive regulation of calcium ion transport|
|response to organophosphorus|
|response to glucocorticoid|
|negative regulation of ion transport|
|response to purine-containing compound|
|placenta development|
|regulation of endothelial cell migration|
|regulation of muscle contraction|
|response to corticosteroid|
|cartilage development|
|female pregnancy|
|cellular response to steroid hormone stimulus|
|cellular response to hypoxia|
|epithelial cell development|
|cellular response to decreased oxygen levels|
|bone development|
|multi-multicellular organism process|
|response to nutrient|
|cellular response to oxygen levels|
|regulation of epithelial cell migration|
|connective tissue development|
|regulation of muscle system process|
|skeletal system morphogenesis|
|regulation of heart contraction|
|regulation of calcium ion transport|
|negative regulation of cell migration|
|ossification|
|negative regulation of cell motility|
|positive regulation of ion transport|
|regulation of blood circulation|
|negative regulation of cellular component movement|
|apical plasma membrane|
|negative regulation of locomotion|
|response to steroid hormone|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|regulation of metal ion transport|
|developmental growth|
|regulation of actin filament-based process|
|growth|
|reproductive structure development|
|reproductive system development|
|pattern specification process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|skeletal system development|
|response to nutrient levels|
|cellular response to lipid|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|cell population proliferation|
|cellular metal ion homeostasis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cell morphogenesis|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of secretion|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|regulation of cell migration|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|animal organ morphogenesis|
|regulation of locomotion|
|positive regulation of transport|
|multi-organism reproductive process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|epithelium development|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|homeostatic process|
|cell development|
|cellular response to stress|
|tissue development|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15995
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STC1 Expression in NALM6 Cells: -1.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>