======= STC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STC2
  * **<color #00a2e8>Official Name</color>**: stanniocalcin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8614|8614]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76061|O76061]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603665|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Stanniocalcin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of multicellular organism growth|
|regulation of store-operated calcium entry|
|decidualization|
|regulation of hormone biosynthetic process|
|response to vitamin D|
|maternal placenta development|
|embryo implantation|
|regulation of hormone metabolic process|
|maternal process involved in female pregnancy|
|regulation of multicellular organism growth|
|response to vitamin|
|hormone activity|
|negative regulation of developmental growth|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|heme binding|
|cellular response to topologically incorrect protein|
|placenta development|
|response to unfolded protein|
|female pregnancy|
|response to topologically incorrect protein|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|multi-multicellular organism process|
|cellular response to oxygen levels|
|response to nutrient|
|negative regulation of growth|
|regulation of calcium ion transport|
|response to endoplasmic reticulum stress|
|endoplasmic reticulum lumen|
|regulation of developmental growth|
|response to hypoxia|
|enzyme binding|
|response to decreased oxygen levels|
|post-translational protein modification|
|response to oxygen levels|
|regulation of metal ion transport|
|response to oxidative stress|
|response to peptide hormone|
|reproductive structure development|
|reproductive system development|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|developmental process involved in reproduction|
|regulation of growth|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|protein homodimerization activity|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|negative regulation of developmental process|
|Golgi apparatus|
|multi-organism reproductive process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to nitrogen compound|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|homeostatic process|
|cellular response to stress|
|negative regulation of gene expression|
|tissue development|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8478
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STC2 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>