======= STIL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STIL
  * **<color #00a2e8>Official Name</color>**: STIL centriolar assembly protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6491|6491]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15468|Q15468]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STIL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STIL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/181590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:9372240}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|floor plate development|
|notochord development|
|protein localization to microtubule organizing center|
|protein localization to centrosome|
|regulation of centriole replication|
|centrosome duplication|
|protein localization to microtubule cytoskeleton|
|embryonic axis specification|
|protein localization to cytoskeleton|
|regulation of centrosome duplication|
|regulation of centrosome cycle|
|heart looping|
|embryonic pattern specification|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|smoothened signaling pathway|
|mitotic spindle organization|
|embryonic heart tube development|
|centrosome cycle|
|multicellular organism growth|
|axis specification|
|neural tube closure|
|tube closure|
|microtubule organizing center organization|
|primary neural tube formation|
|microtubule cytoskeleton organization involved in mitosis|
|neural tube formation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|embryonic epithelial tube formation|
|specification of symmetry|
|epithelial tube formation|
|centriole|
|morphogenesis of embryonic epithelium|
|tube formation|
|spindle organization|
|neural tube development|
|regulation of microtubule cytoskeleton organization|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|heart morphogenesis|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|in utero embryonic development|
|forebrain development|
|developmental growth|
|growth|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|microtubule cytoskeleton organization|
|centrosome|
|heart development|
|regulation of cytoskeleton organization|
|tissue morphogenesis|
|embryonic morphogenesis|
|mitotic cell cycle process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|microtubule-based process|
|mitotic cell cycle|
|protein localization to organelle|
|brain development|
|regulation of cell cycle process|
|head development|
|tube development|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|cell cycle process|
|identical protein binding|
|cytoskeleton organization|
|epithelium development|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell death|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.2|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.87|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.79|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.72|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.74|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.76|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.76|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.77|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.78|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.79|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.81|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.93|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.98|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.2|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.26|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.28|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.31|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.34|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.525|
|[[:human genes:c:cbwd3|CBWD3]]|0.524|
|[[:human genes:c:cbwd6|CBWD6]]|0.524|
|[[:human genes:s:supt5h|SUPT5H]]|0.52|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.519|
|[[:human genes:p:psmb4|PSMB4]]|0.516|
|[[:human genes:c:cbwd5|CBWD5]]|0.514|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.512|
|[[:human genes:t:tfip11|TFIP11]]|0.509|
|[[:human genes:v:vasn|VASN]]|0.502|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.499|
|[[:human genes:p:plk4|PLK4]]|0.497|
|[[:human genes:c:c14orf93|C14orf93]]|0.496|
|[[:human genes:t:twistnb|TWISTNB]]|0.496|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.493|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.489|
|[[:human genes:p:psma6|PSMA6]]|0.478|
|[[:human genes:r:rrp15|RRP15]]|0.475|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.472|
|[[:human genes:s:snrpa1|SNRPA1]]|0.472|
|[[:human genes:v:vps54|VPS54]]|0.471|
|[[:human genes:p:pola1|POLA1]]|0.471|
|[[:human genes:n:nupl1|NUPL1]]|0.47|
|[[:human genes:n:npipb5|NPIPB5]]|0.469|
|[[:human genes:c:copg1|COPG1]]|0.469|
|[[:human genes:c:ccdc94|CCDC94]]|0.465|
|[[:human genes:h:hap1|HAP1]]|0.465|
|[[:human genes:k:kctd17|KCTD17]]|0.464|
|[[:human genes:o:orc1|ORC1]]|0.464|
|[[:human genes:p:polr2f|POLR2F]]|0.462|
|[[:human genes:o:or10g3|OR10G3]]|0.462|
|[[:human genes:n:npipb8|NPIPB8]]|0.461|
|[[:human genes:m:myh2|MYH2]]|0.461|
|[[:human genes:m:mt1e|MT1E]]|0.46|
|[[:human genes:c:cope|COPE]]|0.46|
|[[:human genes:p:psmd3|PSMD3]]|0.46|
|[[:human genes:p:polr2d|POLR2D]]|0.458|
|[[:human genes:z:znf655|ZNF655]]|0.457|
|[[:human genes:p:psmd2|PSMD2]]|0.457|
|[[:human genes:s:slc4a1|SLC4A1]]|0.453|
|[[:human genes:l:lad1|LAD1]]|0.452|
|[[:human genes:p:pole|POLE]]|0.452|
|[[:human genes:n:nup160|NUP160]]|0.45|
|[[:human genes:r:rrn3|RRN3]]|0.45|
|[[:human genes:r:rbbp5|RBBP5]]|0.449|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.449|
|[[:human genes:o:orc6|ORC6]]|0.448|
|[[:human genes:p:pold2|POLD2]]|0.447|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.447|
|[[:human genes:t:ticrr|TICRR]]|0.446|
|[[:human genes:i:iscu|ISCU]]|0.445|
|[[:human genes:s:sart1|SART1]]|0.445|
|[[:human genes:o:ogfr|OGFR]]|0.444|
|[[:human genes:n:nbpf16|NBPF16]]|0.444|
|[[:human genes:c:ccna2|CCNA2]]|0.444|
|[[:human genes:z:znf830|ZNF830]]|0.443|
|[[:human genes:c:cwc22|CWC22]]|0.443|
|[[:human genes:t:tra2b|TRA2B]]|0.443|
|[[:human genes:c:cdc6|CDC6]]|0.443|
|[[:human genes:s:snrnp200|SNRNP200]]|0.442|
|[[:human genes:m:myo1h|MYO1H]]|0.439|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.438|
|[[:human genes:t:tonsl|TONSL]]|0.438|
|[[:human genes:r:rfxank|RFXANK]]|0.437|
|[[:human genes:c:cdc45|CDC45]]|0.436|
|[[:human genes:c:ckap5|CKAP5]]|0.436|
|[[:human genes:m:myb|MYB]]|0.435|
|[[:human genes:p:psmb3|PSMB3]]|0.435|
|[[:human genes:a:arcn1|ARCN1]]|0.434|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.434|
|[[:human genes:r:rnf4|RNF4]]|0.434|
|[[:human genes:c:cdca3|CDCA3]]|0.434|
|[[:human genes:n:nup43|NUP43]]|0.433|
|[[:human genes:r:rps2|RPS2]]|0.432|
|[[:human genes:s:supt6h|SUPT6H]]|0.431|
|[[:human genes:m:myt1l|MYT1L]]|0.431|
|[[:human genes:p:pbxip1|PBXIP1]]|0.431|
|[[:human genes:z:znf106|ZNF106]]|0.431|
|[[:human genes:s:sf3a1|SF3A1]]|0.429|
|[[:human genes:r:rad21|RAD21]]|0.428|
|[[:human genes:f:fbxo5|FBXO5]]|0.428|
|[[:human genes:d:ddtl|DDTL]]|0.428|
|[[:human genes:g:gosr2|GOSR2]]|0.428|
|[[:human genes:r:riok2|RIOK2]]|0.427|
|[[:human genes:u:upf1|UPF1]]|0.424|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.424|
|[[:human genes:p:pola2|POLA2]]|0.422|
|[[:human genes:o:osbp|OSBP]]|0.421|
|[[:human genes:a:aamp|AAMP]]|0.418|
|[[:human genes:a:acsf2|ACSF2]]|0.418|
|[[:human genes:r:rbm39|RBM39]]|0.418|
|[[:human genes:f:fam86b2|FAM86B2]]|0.416|
|[[:human genes:e:exosc5|EXOSC5]]|0.415|
|[[:human genes:r:rpl35|RPL35]]|0.415|
|[[:human genes:g:golga8o|GOLGA8O]]|0.415|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.414|
|[[:human genes:p:poli|POLI]]|0.414|
|[[:human genes:r:rangap1|RANGAP1]]|0.413|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.412|
|[[:human genes:i:ints5|INTS5]]|0.412|
|[[:human genes:o:or11h6|OR11H6]]|0.412|
|[[:human genes:p:psmc2|PSMC2]]|0.411|
|[[:human genes:c:copa|COPA]]|0.411|
|[[:human genes:u:uqcrh|UQCRH]]|0.41|
|[[:human genes:r:rad51|RAD51]]|0.409|
|[[:human genes:t:tspy8|TSPY8]]|0.409|
|[[:human genes:s:sap30bp|SAP30BP]]|0.408|
|[[:human genes:i:igfn1|IGFN1]]|0.407|
|[[:human genes:g:golga6a|GOLGA6A]]|0.405|
|[[:human genes:s:smc3|SMC3]]|0.405|
|[[:human genes:f:fam25b|FAM25B]]|0.405|
|[[:human genes:w:wdr87|WDR87]]|0.405|
|[[:human genes:w:wdr46|WDR46]]|0.404|
|[[:human genes:i:ik|IK]]|0.404|
|[[:human genes:c:cox8a|COX8A]]|0.403|
|[[:human genes:r:rpl38|RPL38]]|0.403|
|[[:human genes:t:timeless|TIMELESS]]|0.402|
|[[:human genes:r:rps28|RPS28]]|0.402|
|[[:human genes:t:tceb3c|TCEB3C]]|0.402|
|[[:human genes:g:gon4l|GON4L]]|0.402|
|[[:human genes:s:snrpb|SNRPB]]|0.401|
|[[:human genes:c:chaf1a|CHAF1A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 104/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|2/28|
|bone|4/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|2/20|
|lung|12/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|9/24|
|peripheral nervous system|3/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|3/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1110
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STIL Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>