======= STIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STIP1
  * **<color #00a2e8>Official Name</color>**: stress induced phosphoprotein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10963|10963]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31948|P31948]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605063|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 1|
|TPR 2|
|Apc3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chaperone complex|
|response to interleukin-7|
|cellular response to interleukin-7|
|Hsp90 protein binding|
|Hsp70 protein binding|
|chaperone binding|
|protein C-terminus binding|
|protein-containing complex|
|Golgi apparatus|
|cellular response to cytokine stimulus|
|response to cytokine|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.14|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.13|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.06|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.97|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.94|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.78|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.73|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.74|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.79|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.84|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.89|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.9|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.9|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.95|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.97|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.98|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.03|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.07|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.11|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.17|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.24|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.25|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.41|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.5|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.54|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.79|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.81|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|4.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:actb|ACTB]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3065
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STIP1 Expression in NALM6 Cells: 8.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>