======= STOM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STOM
  * **<color #00a2e8>Official Name</color>**: stomatin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2040|2040]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27105|P27105]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STOM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STOM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/133090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of acid-sensing ion channel activity|
|positive regulation by host of viral genome replication|
|modulation by host of viral genome replication|
|positive regulation by host of viral process|
|RNA polymerase binding|
|modulation by host of viral process|
|positive regulation of protein targeting to membrane|
|positive regulation of viral genome replication|
|regulation of protein targeting to membrane|
|regulation of sodium ion transmembrane transporter activity|
|azurophil granule membrane|
|positive regulation of viral life cycle|
|regulation of sodium ion transmembrane transport|
|modification by host of symbiont morphology or physiology|
|tertiary granule membrane|
|interaction with symbiont|
|regulation of protein targeting|
|regulation of sodium ion transport|
|specific granule membrane|
|regulation of viral genome replication|
|melanosome|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|positive regulation of protein localization to membrane|
|blood microparticle|
|vesicle|
|regulation of viral life cycle|
|positive regulation of intracellular protein transport|
|modification of morphology or physiology of other organism|
|regulation of cation channel activity|
|regulation of protein localization to membrane|
|regulation of viral process|
|positive regulation of intracellular transport|
|regulation of symbiosis, encompassing mutualism through parasitism|
|membrane raft|
|regulation of intracellular protein transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|protein homooligomerization|
|regulation of intracellular transport|
|cytoskeleton|
|regulation of metal ion transport|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|regulation of ion transmembrane transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|regulation of cellular protein localization|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|protein homodimerization activity|
|regulation of cellular localization|
|leukocyte activation|
|positive regulation of transport|
|secretion by cell|
|endoplasmic reticulum|
|regulation of protein localization|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|mitochondrion|
|integral component of plasma membrane|
|protein-containing complex assembly|
|extracellular space|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18516
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STOM Expression in NALM6 Cells: 3.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>