======= STOML2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STOML2
  * **<color #00a2e8>Official Name</color>**: stomatin like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30968|30968]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJZ1|Q9UJZ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STOML2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STOML2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608292|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:19944461, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitochondrial DNA replication|
|stress-induced mitochondrial fusion|
|positive regulation of cardiolipin metabolic process|
|regulation of cardiolipin metabolic process|
|regulation of mitochondrial DNA replication|
|interleukin-2 production|
|positive regulation of mitochondrial membrane potential|
|cardiolipin binding|
|mitochondrial protein processing|
|positive regulation of DNA-dependent DNA replication|
|positive regulation of membrane potential|
|mitochondrial fusion|
|mitochondrial ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|mitochondrial calcium ion transmembrane transport|
|ATP synthesis coupled proton transport|
|extrinsic component of plasma membrane|
|ATP biosynthetic process|
|GTPase binding|
|positive regulation of DNA replication|
|COP9 signalosome|
|immunological synapse|
|CD4-positive, alpha-beta T cell activation|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|positive regulation of phospholipid metabolic process|
|ribonucleoside triphosphate biosynthetic process|
|regulation of DNA-dependent DNA replication|
|purine ribonucleoside triphosphate metabolic process|
|alpha-beta T cell activation|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|regulation of mitochondrial membrane potential|
|mitochondrial intermembrane space|
|regulation of phospholipid metabolic process|
|mitochondrial transmembrane transport|
|nucleoside triphosphate metabolic process|
|organelle fusion|
|regulation of DNA replication|
|oxidative phosphorylation|
|T cell receptor complex|
|positive regulation of lipid metabolic process|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|cytokine production|
|purine nucleotide biosynthetic process|
|protein processing|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|T cell receptor signaling pathway|
|calcium ion transmembrane transport|
|ATP metabolic process|
|mitochondrial transport|
|actin cytoskeleton|
|protein maturation|
|membrane raft|
|T cell activation|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|calcium ion transport|
|antigen receptor-mediated signaling pathway|
|divalent metal ion transport|
|divalent inorganic cation transport|
|purine ribonucleotide metabolic process|
|lipid localization|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|signaling receptor binding|
|ribose phosphate metabolic process|
|cytoskeleton|
|purine-containing compound metabolic process|
|lymphocyte activation|
|mitochondrial inner membrane|
|regulation of lipid metabolic process|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|mitochondrion organization|
|nucleotide metabolic process|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|nucleoside phosphate metabolic process|
|cellular divalent inorganic cation homeostasis|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|drug metabolic process|
|protein complex oligomerization|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|positive regulation of immune response|
|organophosphate metabolic process|
|cellular homeostasis|
|leukocyte activation|
|ion transmembrane transport|
|carbohydrate derivative metabolic process|
|cell activation|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|proteolysis|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|cellular response to stress|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.82|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.74|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.76|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.77|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.77|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.78|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.8|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.82|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.88|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2715
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STOML2 Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>