======= STPG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STPG1
  * **<color #00a2e8>Official Name</color>**: sperm tail PG-rich repeat containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90529|90529]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TH74|Q5TH74]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STPG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STPG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615826|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. {ECO:0000269|PubMed:23028632}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein homodimerization activity|
|positive regulation of mitochondrial membrane permeability involved in apoptotic process|
|mitochondrial outer membrane permeabilization involved in programmed cell death|
|positive regulation of mitochondrial membrane permeability|
|regulation of protein homodimerization activity|
|positive regulation of membrane permeability|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|apoptotic mitochondrial changes|
|regulation of mitochondrial membrane permeability|
|regulation of membrane permeability|
|positive regulation of protein binding|
|mitochondrial membrane organization|
|positive regulation of binding|
|mitochondrial transport|
|regulation of protein binding|
|regulation of binding|
|mitochondrion organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|molecular function|
|membrane organization|
|apoptotic process|
|programmed cell death|
|cell death|
|mitochondrion|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.14|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.89|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.75|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.73|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.77|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.79|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.84|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.87|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.91|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.11|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16469
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STPG1 Expression in NALM6 Cells: 2.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>