======= STRC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STRC
  * **<color #00a2e8>Official Name</color>**: stereocilin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=161497|161497]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7RTU9|Q7RTU9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STRC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STRC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential to the formation of horizontal top connectors between outer hair cell stereocilia. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kinocilium|
|auditory receptor cell stereocilium organization|
|detection of mechanical stimulus involved in sensory perception of sound|
|auditory receptor cell morphogenesis|
|auditory receptor cell development|
|stereocilium tip|
|inner ear auditory receptor cell differentiation|
|inner ear receptor cell stereocilium organization|
|detection of mechanical stimulus involved in sensory perception|
|hair cell differentiation|
|inner ear receptor cell development|
|neuroepithelial cell differentiation|
|detection of mechanical stimulus|
|columnar/cuboidal epithelial cell development|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|columnar/cuboidal epithelial cell differentiation|
|inner ear morphogenesis|
|ear morphogenesis|
|detection of external stimulus|
|detection of abiotic stimulus|
|cell-matrix adhesion|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|cell-substrate adhesion|
|epithelial cell development|
|inner ear development|
|response to mechanical stimulus|
|ear development|
|sensory organ morphogenesis|
|embryonic organ morphogenesis|
|epidermal cell differentiation|
|epidermis development|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|detection of stimulus involved in sensory perception|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|cell surface|
|neuron projection development|
|epithelial cell differentiation|
|detection of stimulus|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|nervous system process|
|generation of neurons|
|neurogenesis|
|cell development|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12220
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STRC Expression in NALM6 Cells: 2.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>